Motilium: indispensable for poisoning and stomach disorders

Updated: 04/23/2021 15:12:56

Expert: Abramova Tsilya

Antiemetics are used for various diseases of the stomach, esophagus and intestines. Representatives: Motilak and Motilium. These medicines contain domperidone in an amount of 10 mg. Their actions are similar, but there are some differences that you need to become familiar with before starting treatment.

What is Motilium

The active component of the drug is domperidone, a substance that can quickly suppress nausea, normalize peristalsis, stool, and relieve signs of indigestion. The product is produced in several pharmaceutical forms:

• film-coated tablets: white, biconvex, containing 10 mg of domperidone, packaged in blisters;
• non-coated sublingual tablets with mint flavor;
• syrup for children: a sweetish, thick, white, water-based liquid with a dosage of domperidone 1 mg per 1 ml, sold in glass bottles with a measuring syringe.

The tablet medicine contains auxiliary compounds: starch, povidone, stabilizers.

Similar drugs, their differences and costs

Analogs and synonyms of Motilium can often quite adequately replace the original, but only the replacement options should be selected by the attending physician, especially in the case of infants and children.

Ganaton

Ganaton belongs to the prokinetic group of drugs, which improve the motility of the gastric walls and accelerate the evacuation of food, eliminating severe symptoms caused by food retention. Motilium, in addition to these conditions, is also capable of providing an antiemetic effect.

What does it mean:

1. To eliminate heartburn and belching, nausea and a feeling of fullness, epigastric pain, gastric or esophageal pathologies, you can take both Motilium and Ganaton, and the latter will even be somewhat more effective.
2. But for the treatment of nausea and vomiting reactions provoked by medications, gastrointestinal pathologies or intestinal infections, digestive disorders, you need to use Motilium, and Ganaton will be useless in this situation.

Motilak

Motilak and Motilium are considered synonyms, since both drugs have the same active substance - domperidone.

In fact, Motilium and Motilak have the same therapeutic effect, but only Motilium is less likely to cause adverse reactions. If the patient is prone to various side effects, then it is better to choose Motilium for treatment.

Moreover, Motilak is produced only in tablet form, and Motilium is produced in suspension form especially for infants. Therefore, only Motilium is used in pediatrics.

Trimedat

The drug is a myotropic antispasmodic that regulates digestive motility and peristalsis.

Prescribed for gastrointestinal motility disorders, gastroesophageal reflux or dyspepsia, obstruction or irritable bowel syndrome. In children, Trimedat can be used from 3 years of age.

Trimedat belongs to a slightly different pharmaceutical group than Motilium, which is more effective as an antiemetic and other disorders in the activity of the upper gastrointestinal tract structures. Therefore, it is difficult to compare them.

Cerucal

The drug Cerucal has an anti-hiccup and anti-emetic effect, suppressing reflexes at the nervous system level.

• The drug blocks serotonin and dopamine receptors.
• In addition, Cerucal is prescribed to patients with hypotension or atony of intestinal structures, diabetic gastroparesis, digestive disorders, etc.
• Cerucal in tablets is contraindicated for use in children, while Motilium in the form of syrup can be taken even by infants.

Espumisan

The medication Espumisan is intended to eliminate excess gas formation. It is produced in the form of a suspension and drops. In fact, the drug is a defoamer, eliminating bubbles and simplifying the removal of gases from the intestines.

For what diseases is Motilium needed?

The medicine helps restore well-being in the following pathologies:

• stomach ulcer;
• atonic bowel dysfunction;
• flatulence;
• hypokinetic dyskinesia of the gallbladder;
• epigastric pain;
• nausea, vomiting due to food or chemical intoxication;
• digestive disorders due to taking medications, radiation therapy;
• spontaneous constipation;
• frequent regurgitation in children.

The drug moderately stimulates intestinal peristalsis, normalizing gastric functions and eliminating signs of dyspepsia. Domperidone suppresses dopamine activity, producing a mild antipsychotic effect. But, unlike other drugs, it does not lead to autonomic disorders.

The medicine quickly penetrates the blood through the mucous membranes and interacts with its proteins. After administration, Motilium cleanses the stomach cavity, intestinal lumen, binds and neutralizes toxic substances. It is completely excreted from the body with intestinal contents after 12–24 hours, without accumulating in tissues.

Analogues of Motilium for children and adults

Motilium suspension for children and tablets are used to treat digestive disorders. They eliminate nausea, vomiting, pain and heaviness in the stomach, and a feeling of fullness after eating. The cost of the drug starts from 550 ₽ for 30 tablets or a bottle.

The medicine is expensive and not available to all segments of the population, especially with a long course of treatment. The issue of selecting Motilium analogues should be discussed with your doctor.

Indications for use of Motilium

The medicine is used to eliminate nausea and vomiting caused by organ pathologies, diseases, dietary errors, and the use of medications.

Since Motilium eliminates food stagnation in the stomach and enhances intestinal motility, it can be used to eliminate:

• heartburn;
• belching;
• nausea;
• vomiting;
• feeling bloated and full after meals;
• flatulence;
• epigastric pain.

Tablets are used in children weighing more than 35 kg and adults, suspension - in small children.

Motilium - instructions for use

The medicine is taken 3-4 times a day, 1-2 tablets. The syrup is used for its intended purpose, the dosage is calculated based on the child’s weight and the presence of concomitant kidney diseases.

The medicine should not be used for moderate to severe liver diseases or gastrointestinal bleeding. Since the drug negatively affects the functional parameters of the liver, it cannot be used simultaneously with hepatotoxic drugs, i.e.

medications harmful to this organ. The list includes antibiotics (Erythromycin, Clarithromycin), antifungals (Ketoconazole, Fluconazole), heart drugs (Amiodarone, Diltiazem, Verapamil), etc.

A detailed list is provided in the insert in the “Interactions” section.

Motilium before or after meals

The medicine is taken before meals to prevent food stagnation and improve intestinal motility. Regular tablets are washed down with water; dispersible tablets with the Express attachment dissolve in 2–3 seconds in the oral cavity.

The suspension can be taken as directed. First you need to shake gently, avoiding foaming.

Analogues of Motilium

The medicine is used to eliminate many dyspeptic symptoms. The cost of 30 tablets is quite high. For an adult they last up to 10 days. Motilium substitutes differ in active substances, pharmacological group, and indications. Depending on the symptoms and cause, the following groups may be prescribed:

• enzyme preparations;
• synonyms – analogues according to INN;
• antidiarrheals;
• antacids;
• antispasmodics;
• sorbents;
• agents that regulate intestinal motility.

The choice of a cheap Motilium substitute should be entrusted to a gastroenterologist to determine the cause of dyspepsia and comprehensive treatment.

Motilium and structural analogues can be used on their own for up to 28 days without a doctor’s prescription, provided there are no side effects or worsening of the condition.

List of analogues on the Russian market with approximate prices

Synonyms

Motilium is presented in syrup for young patients and tablets for older children and adults. A synonym or analogue for the active substance in the form of a suspension based on domperidone is the Indian drug Motinorm. It is rarely found in pharmacies, it has been allowed since the year.

The drugs differ in technology and manufacturer, frequency of side effects and price. The high cost of Motilium is explained by the high costs of development and clinical research.

How to replace Motilium if treatment with the drug is not affordable:

• Passengers;
• Domperidone;
• Motonium;
• Motilak.

The difference between Passazhix and other synonyms is the convenient and fast-acting form of chewable tablets.

Enzyme preparations

If dyspeptic symptoms are associated with insufficient secretion of enzymes, Motilium can be replaced with a drug from this group.

Representatives:

• Pancreatin;
• Creon;
• Mezim;
• Enzistal;
• Festal;
• Hermital;
• Panzinorm et al.

Medicines compensate for the lack of enzymes necessary for the digestion and absorption of food and eliminate dyspeptic symptoms. Disadvantage: with constant use and abuse, the synthesis of enzymes in the body is disrupted.

Antacids

Drugs in this group are used for heartburn and stomach pain. They envelop the gastric mucosa, protecting against the negative effects of hydrochloric acid and other irritants.

Representatives:

• Maalox;
• Rennie;
• Phosphalugel;
• Gaviscon;
• Gastal et al.

Some medications can cause constipation.

Motilium analogues from the antacid group are used for symptomatic relief of heartburn, they do not treat it.

Duspatalin

Manufacturer: Mylan or Veropharm, Russia or Korea

Release form: tablets, capsules

Active ingredient: mebeverine

Synonyms: Niaspam, Sparex, Mebeverine

The medicine in tablets and capsules Duspatalin is used for pain and cramps in the intestines. The main component of the analogue is mebeverine. The product normalizes peristalsis and treats irritable bowel syndrome. This is a condition characterized by pain, stool disturbance, changes in its frequency, and flatulence. Not used in pediatrics.

The drug No-spasm has a similar effect to Duspatalin.

Smecta

Manufacturer: Bofur Ipsen Industry, France

Release form: powder or suspension

Active ingredient: dioctahedral smectite

Synonyms: Diosmectite, Neosmectin, Endosorb

Smecta is an analogue of Motilium in suspension or powder for its preparation, suitable for adults and children. Belongs to the group of antidiarrheal drugs. Acts in the lumen of the small intestine. This analogue of Motilium for children in suspension adsorbs bacteria, viruses, toxins, and allergens that cause diarrhea on the surface.

The advantage of Smecta is its low price, the disadvantage is its unpleasant taste.

Espumisan

Manufacturer: Berlin-Chemie, Germany

Release form: capsules, solution in drops

Active ingredient: simethicone

Synonyms: Bobotik, Sub Simlex, Simethicone with fennel, Espumisan extra

An analogue of Motilium syrup and tablets is the drug Espumisan, which is classified as a carminative. When it enters the gastrointestinal tract, it collapses gas bubbles and is excreted unchanged.

The imported analogue is used to eliminate bloating, flatulence, and colic in newborns. It is actively prescribed before examining the abdominal organs for accurate x-ray diagnostics.

The advantage of Espumisan is safety, possibility of use from the first days of life, small capsule size. The latter form can be swallowed without drinking water.

Enterofuril

Manufacturer: Bosnalek, Bosnia and Herzegovina

Release form: capsules, syrup

Active ingredient: nifuroxazide

Synonyms: Nifuroxazide, Elufor, Mirofuril, Ecofuril, Contrdiar, Nifural, Adisorb, Stopdiar

The drug Enterofuril is used to treat bacterial diarrhea. Belongs to the group of nitrofurans, antimicrobial agents. It can be used in the form of syrup from a month onwards and has a pleasant banana taste. The effect of the medicine occurs on the first day after use.

Other antidiarrheal drugs:

• Imodium (Russian analogue – Loperamide);
• Enterosgel;
• Polysorb;
• Furazolidone and others.

Motilium or Motilak – which is better?

Manufacturer: Veropharm, Russia

Release form: tablets

Active ingredient: domperidone

Both drugs are used to restore gastrointestinal contractility. Eliminate abdominal pain, heartburn, bloating, heaviness in the abdomen and nausea. There is only one active ingredient – ​​domperidone.

The difference between drugs is in the form of release, manufacturer and pricing policy. Motilium is a regular and orally soluble tablet and suspension. Motilak is available in film-coated tablets. The cost of the second one is lower.

Motilium and Motilak are synonyms. However, for the quality, variety of release forms and the ability to use the express formula in early childhood, many patients and doctors prefer Motilium. The quality and effectiveness have been confirmed by clinical studies, on the basis of which the instructions have been compiled.

Motilium in syrup is better for a child. If the weight is more than 35 kg, you can replace it with an analogue - Motilak.

Motilium or Cerucal

Manufacturer: Merkle or Pliva, Germany or Croatia

Release form: tablets, injection solution

Active ingredient: metoclopramide

Medicines Cerucal and Motilium are antiemetics.

Cerucal is a prescription drug in tablets and ampoules, used for nausea and vomiting as prescribed by a doctor. Has many side effects. The cost of this analogue of Motilium is low - 100 tablets 120–160 rubles.

Motilium is prescribed not only for nausea and vomiting, but also for the treatment and relief of dyspeptic disorders. Available in suspension and regular and dispersible tablets.

Analogs have antiemetic properties and differ in composition and scope of application. In emergency cases, with nausea and vomiting, Cerucal is better for children and adults; for bloating, heaviness and heartburn, Motilium is more effective. Both analogues are imported.

Motilium or Ganaton - which is better?

Manufacturer: Mailan, Japan

Release form: tablets

Active ingredient: itopride

Synonyms: Itomed, Retch, Itopra

An analogue of Motilium tablets is the Japanese drug Ganaton, often prescribed for GERD, and has positive reviews from doctors and patients. The medicine belongs to the group of stimulants of gastrointestinal motility and stimulators of acetylcholine release. Age limit – up to 16 years. Prescribed for dyspeptic symptoms and gastrointestinal motility disorders (reflux).

Motilium is available in additional forms - soluble tablets and syrup, and is used in pediatrics. It also affects intestinal motility and eliminates dyspeptic disorders.

The choice of medication and form is discussed with the doctor based on the diagnosis, symptoms, concomitant diseases, and restrictions.

Motilium or Domperidone – which is better?

Manufacturer: Alsi Pharma, Ozon, Russia

Release form: tablets

Active ingredient: domperidone

Domperidone and Motilium - drugs with the same composition, are synonymous. They have the same indications, contraindications, and side effects.

A significant disadvantage of the domestic analogue of Domperidone is the low quality of raw materials (from India or China) and the frequent occurrence of side effects. The cost of the substitute is several times lower.

Another difference between Domperidone and Motilium is the release form. Pharmacies stock only regular tablets; the imported analogue is presented in display cases as dispersible tablets and syrup for children.

Motilium or Trimedat

Manufacturer: Valenta Pharm, Russia

Release form: tablets

Active ingredient: trimebutine

Synonyms: Neobutin, Neobutin retard, Trimedat forte

For GERD, Motilium or Trimedat may be prescribed. The first medicine has an antiemetic effect and regulates gastrointestinal motility. The second drug can replace Motilium for adults. Refers to antispasmodics that normalize intestinal motility.

The analogue of Motilium Trimedat is cheaper and is prescribed for children from 3 years of age. Indications: reflux disease, dyspeptic disorders, impaired intestinal motility (increased or decreased).

The drugs have similar actions, but different composition and mechanism. In each individual case, the choice is made based on the characteristics of the disease.

Motilium analogues are drugs from different pharmacological groups: antispasmodics, gastrointestinal motility regulators, antidiarrheals, sorbents, antacids, enzyme preparations. To make the right choice, consult your doctor for a diagnosis and determine the cause of the condition.

Answers on questions

1. Motilium or Motilium Express – which is better?
   According to the manufacturer's research, the Express form is 50 times more effective and acts faster. It is a tablet that dissolves in the mouth in 2-3 seconds and does not require drinking water. This saves time on dissolving the shell.
2. Does Motilium help with diarrhea or not?
   There is no indication for diarrhea in the instructions for use. However, the medicine normalizes intestinal motility and can be used as an additional remedy.
3. Does Motilium help with heartburn or not?
   Yes, the medicine is effective for heartburn.
4. What is better - Motilium tablets or suspension?
   For children, a suspension is better; for adults, Motilium Express in the form of dispersible tablets is more effective and profitable.

Source: https://LekAnalog.ru/motilium-analogi/

How to take Motilium tablets

Adults are recommended to take 1 pill three times a day, 15–20 minutes before meals. The coated tablets are washed down with cool or warm water. Sublingual - placed under the tongue until completely dissolved. If necessary, the single dose is increased 2–3 times. The maximum number of tablets per day is 8 pcs. It is allowed to take the medicine before bedtime.

For children, treatment with Motilium in tablets is recommended from 6–7 years of age: 1 tablet 2–3 times a day. For body weights less than 35 kg, it is recommended to use a suspension of the drug.

Description of Motilak

Motilak is an antiemetic drug based on domperidone. Produced by Veropharm in Russia. Available in tablet form. Affects the peristalsis of the stomach and duodenum. Increases the tone of the esophageal sphincter. Prevents the occurrence of nausea and vomiting. Improves stomach function, speeding up emptying.

Domperidone is a prokinetic agent. It is a dopamine receptor antagonist. Domperidone accelerates the peristalsis of the stomach and intestines and provokes the release of prolactin. The substance is used to normalize the function of the gastrointestinal tract.

Contraindications

Motilak is contraindicated if intolerance to the active ingredient, namely domperidone, has previously been established. It is also not used when there is an allergy or hypersensitivity to the excipients in the composition.

It is not recommended to use the medicine when stimulation of gastric motility may worsen the condition. The drug is contraindicated in case of gastric bleeding, perforation and organ obstruction. Also, it should not be used when there is prolactinoma.

Animal studies have shown that domperidone is not teratogenic. Motilak can be used in the first trimester of pregnancy, when the expected benefits outweigh the possible risks. During lactation, it is unknown whether the concentration of domperidone that enters the milk has a negative effect on the child. It is recommended to temporarily stop breastfeeding when there is a need to undergo treatment with Motilac.

Side effects

Motilak is well tolerated. In rare cases, intestinal spasms have been reported. Extrapyramidal effects may appear in adults, but are temporary and disappear completely after treatment is stopped. Motilac can lead to an increase in plasma prolactin levels. This phenomenon can already provoke gynecomastia and galactorrhea.

There is a possibility of allergic manifestations. Cases of urticaria and rash were recorded.

Dosage

Motilak is taken before meals. For nausea and vomiting – 20 mg 3-4 times. For frequently recurring symptoms of dyspepsia - 10 mg 3-4 times. The dose may be doubled. For kidney disease, the medicine is taken no more than 2 times a day with a possible reduction in dosage.

In case of overdose, extrapyramidal reactions, drowsiness, and spatial disorientation are observed. Activated carbon is prescribed for treatment. Anticholinergics may be effective for extrapyramidal reactions.

In case of renal failure, the drug is prescribed with caution. During long-term treatment, you need to be regularly examined by a doctor and be monitored.

Who is it suitable for?

Motilak is prescribed for dyspeptic symptoms associated with slow gastric emptying, esophagitis, and reflux. The drug helps with heaviness in the stomach, a feeling of fullness, and pain in the epigastric zone. Also indicated for heartburn with or without reflux.

Effective for vomiting of organic, functional, infectious origin. A special indication is the treatment of Parkinson's disease with dopamine antagonists, which leads to nausea and vomiting.

Side effects of Motilium

The drug increases the synthesis of the hormone prolactin. In some cases, this can cause a short-term disruption of the menstrual cycle and provoke the development of gynemastia. Occasionally during treatment the following are possible:

• decreased appetite;
• dryness or unpleasant taste in the mouth;
• increased drowsiness;
• increased spasms in the intestines.

If any undesirable symptoms occur, you should consult your doctor.

Which drug is better

Motilak and Motilium are analogues. They have the same indications. Side effects and contraindications differ, so you need to carefully read the instructions for each drug. Both drugs can be prescribed for the shortest possible course.

Motilium is more suitable for children, as is the case for women during pregnancy. The suspension can even be used to treat infants.

Motilak costs almost twice as much, as it is produced in Russia. Motilium is a Belgian drug.

When you need to quickly relieve nausea, you can use Motilak dissolving tablets. If the symptoms of dyspepsia are constant, you need to be examined by a doctor who will select the most effective and safe medications for your particular case.

When is Motilium contraindicated?

It is prohibited to use the medicine:

• in case of danger of perforation of a gastric ulcer, development of internal bleeding;
• in case of intestinal obstruction;
• in case of dysfunction, neoplasms in the pituitary gland;
• prolactinoma;
• severe kidney or liver damage;
• individual intolerance to any of the components of the drug.

If you are allergic to Motilium, itching, hyperemia, rash, lacrimation, and swelling of the mucous membranes are likely to occur. In such cases, discontinuation of therapy and replacement of the drug with another is required.

How does Motilium interact with other drugs?

During the period of using Motilium, it is advisable to stop using antacids and proton pump inhibitors - drugs that reduce the acidity of gastric juice. Simultaneous use slows down the action of Motilium and reduces its absorption.

Antimycotic drugs and drugs from the macrolide group inhibit the metabolism of domperidone. This is important to consider in cases of impaired renal and liver function.

When undergoing treatment with Ketoconazole, Azithromycin, Erythromycin and inhibitors of the CYP3A4 isoenzyme, Motilium should be discontinued. Otherwise, the risk of heart failure increases.

How can I replace Motilium?

The most famous analogues and generics of the drug:

• Domrid;
• Domidon;
• Domperidone Hexal;
• Motinorm;
• Motoricum;
• Motilak;
• Peridonium.

You should not change the medicine to an alternative one on your own. In addition to differences in dosage, some of them have a wider list of contraindications; not all are approved for use in pediatrics.