MOTILAK tab 10mg N30

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What pills help with a hangover?
Effective hangover pills based on natural ingredients
Other drugs to combat hangover
Zorex

Withdrawal syndrome or hangover is a condition caused by the toxic effect of alcohol, accompanied by a complex of disturbances in the functioning of internal organs. When you have a hangover, you may experience acute symptoms: nausea, unbearable migraine, dizziness, and bouts of vomiting. Special anti-hangover pills will quickly relieve such symptoms, normalize your well-being, help remove toxic substances from the body, and prevent dehydration.

Composition and release form

Film-coated tablets	1 table
domperidone	10 mg
excipients: potato starch; lactose; MCC; Aerosil; polyvinylpyrrolidone; magnesium stearate; sodium carboxymethyl starch; hydroxypropylcellulose; twin 80; titanium dioxide; colloidal silicon dioxide

in a blister pack 10 pcs.; in a cardboard pack 1 or 3 packs.

Lozenges	1 table
domperidone	10 mg

in a blister pack 10 pcs.; in a cardboard pack 1 or 3 packs.

Pharmacokinetics

Suction

After oral administration, it is quickly absorbed from the gastrointestinal tract. It has low bioavailability (about 15%). Reduced acidity of gastric contents reduces the absorption of domperidone. Cmax in plasma is reached after 1 hour.

Distribution

Domperidone is widely distributed in tissues; its concentration in brain tissue is low. Plasma protein binding is 91–93%.

Metabolism

Subject to intensive metabolism in the intestinal wall and liver.

Removal

Excreted through the intestines (66%) and kidneys (33%), unchanged, 10 and 1% of the dose, respectively. T1/2 - 7–9 hours (with severe renal failure it is prolonged).

Indications for the drug Motilak®

A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis;

- feeling of fullness in the epigastrium, feeling of bloating, pain in the upper abdomen;

- belching, flatulence;

- heartburn with or without reflux of stomach contents into the oral cavity.

Nausea and vomiting of functional, organic, infectious origin, caused by radiotherapy, drug therapy or diet disorders. A specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson's disease (such as L-dopa and bromocriptine).

Use during pregnancy and breastfeeding

When administered to animals in doses up to 160 mg/kg/day, it has no teratogenic effect. Use in the first trimester of pregnancy is possible if the expected effect of therapy exceeds the potential risk to the fetus. There is currently no evidence of an increased risk of developmental defects in humans. In women, concentrations of domperidone in breast milk are 4 times lower than the corresponding concentrations in plasma. It is unknown whether this level has a negative effect on newborns. Therefore, if the mother is taking Motilac, breastfeeding is not recommended unless the expected benefit justifies the potential risk.

Side effects

Side effects are rare. Exceptional cases of transient intestinal cramps have been reported.

Extrapyramidal effects are rarely observed in children and are an exception in adults. These phenomena are completely reversible and disappear spontaneously after cessation of treatment.

Since the pituitary gland is located outside the BBB, Motilac can induce an increase in plasma prolactin levels. In rare cases, this hyperprolactinemia can stimulate the appearance of galactorrhea and gynecomastia.

Rare allergic reactions such as rash and hives have been reported.

Motilak analogues (structural substitutes)

Level 4 ATX code matches:
Passazhix

Motinorm

Domrid

Motilium

Itomed

Metoclopramide

Domperidone

Ganaton

Cerucal

Motinorm , Motorix , Peridon , Motoricum . Analogues of Motilak are produced in Russia and abroad.

Interaction

Anticholinergic drugs neutralize the effect, antacid and antisecretory drugs reduce bioavailability, inhibitors of the cytochrome P450 CYP3A4 isoenzyme (antifungals of the azole group, antibiotics of the macrolide group, HIV protease inhibitors, nefazodone) increase plasma levels. It is possible that concomitantly used drugs with sustained release of the active substance may have an effect on absorption. Domperidone does not affect the level of paracetamol and digoxin in the blood.

Zorex

Available in the form of capsules, which include:

unithiol;
calcium pantothenate.

These substances have a powerful detoxification effect and help quickly remove such dangerous poisons from the body as:

alcohol metabolites;
heavy metal salts:
arsenic compounds.

The drug firmly binds and quickly removes toxic compounds, facilitating the functioning of the kidneys and liver. Zorex is suitable for emergency cases when you need to quickly get rid of a hangover.

Alka-prim

Consists of components:

acetylsalicylic acid;
soda;
glycine.

The drug is sold in the form of effervescent tablets. To relieve a hangover, you need to dissolve two tablets in a glass of water and drink. If the withdrawal syndrome is very severe, it is allowed to take 4 such doses throughout the day.

Antipohmelin

Sold as chewable lozenges. They contain specific acids that neutralize the negative effects of ethanol. The drug helps not only get rid of unpleasant symptoms, but also prevent the hangover itself. To do this, before the feast itself and throughout the banquet, it is recommended to periodically chew lozenges.

Tablets are ineffective in case of developed alcohol poisoning, since they do not have a sorption effect that allows them to bind and remove toxic breakdown products of ethanol from the body.

Zenalk

Effectively combats the negative consequences of intoxication. The drug contains extracts of the following plants:

logo;
terminalia chebula;
chicory;
date palm.

Effect of using capsules:

slowing down the rate of ethanol oxidation and preventing its accumulation in the liver;
intensive removal of toxic substances;
eliminating severe hangover symptoms.

The drug improves metabolism, protects hepatocytes from the destructive effects of harmful toxins, and has a powerful antioxidant effect.

Buffalo

The main active ingredients of the drug are succinic acid and sodium bicarbonate. It is advisable to take the tablets in the morning after the banquet. They effectively cleanse the liver of poisons, restore oxidative processes, normalize hydrobalance, and quickly relieve symptoms of alcohol intoxication.

Medichronal

The composition contains substances that have a powerful cleansing and metabolic function improving effect:

sodium formate;
glucose.

The drug is intended to relieve severe withdrawal symptoms. Sodium formate instantly penetrates the blood, neutralizing the breakdown products of ethanol. Glucose nourishes the cells of internal organs and accelerates the elimination of toxins.

What medications can help prevent a hangover?

Preventing withdrawal symptoms is much easier than dealing with its consequences. To do this, before the feast, it is recommended to drink one of the following drugs:

Enterosgel. To prevent an acute hangover, it is recommended to drink three tablespoons of the gel after a banquet and the same amount immediately after waking up. The drug quickly binds and removes toxins, relieving hangovers and pathological symptoms.
Activated carbon. The drug prevents the absorption of alcohol, making the symptoms of alcohol intoxication much less disturbing. 10 - 15 minutes before the feast you need to drink 4 tablets, then take 2 tablets every 1 - 1.5 hours.
Almagel. Has an astringent effect. The suspension should be drunk 10 - 15 minutes before the feast in the amount of 2 - 3 tablespoons. Then take the product every 30 to 40 minutes.
Vitamins B and C. These are powerful antioxidants that accelerate the removal of toxins from the body, preventing alcohol intoxication.

In addition to taking medications, it is advisable to adhere to the rules that will significantly ease the hangover syndrome:

Drink plenty of fluids. An adult struggling with alcohol intoxication should drink at least 5 glasses of regular drinking water every hour. This is a moderate fluid load, which increases diuresis and promotes intensive elimination of toxins naturally. However, it is worth noting that with diseased kidneys, drinking too much can cause a worsening of the condition, but if everything is in order with health, such a water load does not pose any danger. In addition to water, you can drink fruit drinks, freshly squeezed juices, compotes, green tea with honey.
Eat properly. During the feast, you should not indulge in heavy food, the digestion of which only increases the load on the body. Immediately before the banquet, it is recommended to eat a bowl of buckwheat, rice or oatmeal. Any of the selected dishes will normalize the functioning of the digestive tract, so that toxins will leave the body much faster. During a banquet, nutritionists advise to indulge in vegetable salads and juicy fruits, but it is better to avoid fatty meats, smoked meats, and mushroom dishes.
Normalize sleep. During sleep, the human body recovers and more efficiently . Before going to bed, it is advisable to ventilate the bedroom, and if the weather outside allows it, leave the window open all night. Adequate sleep will allow you to wake up in the morning with a fresh head and avoid a severe hangover.
Give up coffee. Caffeine-containing drinks have a strong diuretic effect, promoting intense loss of fluid, which is already insufficient in the body during alcohol intoxication. Fluid deficiency causes blood to thicken, as a result of which the load on the heart increases significantly.
To walk outside. Short walks in the fresh air have a beneficial effect on the entire body, saturating cells with oxygen and promoting their active regeneration. After walking unpleasant hangover symptoms such as headache, nausea, and dizziness disappear.
Take a refreshing shower. Water at room temperature tones blood vessels, normalizes blood pressure, and cleanses skin pores of impurities and toxins.

Directions for use and doses

Inside, 15–20 minutes before meals.

Adults in cases of acute nausea or vomiting: 20 mg 3-4 times a day and before bedtime.

For chronic dyspeptic symptoms: 10 mg (1 tablet) 3-4 times a day and, if necessary, before bedtime. If necessary, the indicated dose is doubled.

For patients with severe renal impairment, when re-prescribed, the frequency of administration should not exceed 1-2 times a day; it may be necessary to reduce the dose of the drug (depending on the severity of the deficiency).

Other drugs to combat hangover

Relieving a hangover with pills is the fastest and most effective way, allowing you to immediately return to a full life and restore the normal functioning of the entire body. Medicines to combat hangover have a number of useful properties:

quickly remove toxic substances from the body;
relieve thirst, unpleasant taste and dry mouth;
stabilize hydrobalance;
eliminate migraines, dizziness, nausea.

It is recommended to take hangover medications strictly following the dosage suggested in the instructions. It is advisable to take the drug with regular drinking water without gas or sweeteners. Each medicine to combat hangover has contraindications , which are important to consider before drinking. An overview of the most effective and affordable drugs against withdrawal symptoms is provided below:

Alka Seltzer

Many people have appreciated the real benefits of the drug, which includes:-

sodium bicarbonate;
acetylsalicylic and citric acid.

Within half an hour after use, the product helps eliminate the following symptoms:

migraine;
attacks of nausea;
heartburn.

The effervescent tablets dissolve in water and the finished drink tastes good. In addition to relieving unpleasant symptoms, the drug reduces the load on the heart by thinning the blood. However, it is not recommended to use Alka-Zkltser for people with a tendency to internal bleeding , diseases of the hematopoietic system, as well as for women during menstruation.

Precautionary measures

Given the metabolism of domperidone in the liver, Motilak should be prescribed with caution to patients with liver failure.

In patients with severe renal failure (serum creatinine > 6 mg/100 ml, i.e. > 0.6 mmol/l), T1/2 of domperidone increased from 7.4 to 20.8 hours, but plasma concentrations of the drug were lower than in healthy volunteers. Since a very small percentage of the drug is excreted unchanged by the kidneys, single dose adjustment is unlikely to be necessary in patients with renal failure. However, when re-prescribed, the frequency of administration should be reduced to 1-2 times a day, depending on the severity of the deficiency, and it may also be necessary to reduce the dose. During long-term therapy, patients should be monitored regularly.

Oral tablets Motilak

Instructions for medical use of the drug

Description of pharmacological action

Prokinetic. Increases the duration of peristaltic contractions of the antrum of the stomach and duodenum, improves the functioning of the stomach, accelerating its emptying if this process slows down, increases the tone of the lower esophageal sphincter, and eliminates the development of nausea and vomiting.

Indications for use

A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis; - feeling of fullness in the epigastrium, feeling of bloating, pain in the upper abdomen; - belching, flatulence; - heartburn with or without reflux of stomach contents into the oral cavity. Nausea and vomiting of functional, organic, infectious origin, caused by radiotherapy, drug therapy or diet disorders. A specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson's disease (such as L-dopa and bromocriptine).

Release form

Film-coated tablets 1 tablet. domperidone 10 mg excipients: potato starch; lactose; MCC; Aerosil; polyvinylpyrrolidone; magnesium stearate; sodium carboxymethyl starch; hydroxypropylcellulose; twin-80; titanium dioxide; colloidal silicon dioxide in blister packs 10 pcs.; in a cardboard pack 1 or 3 packs.

Pharmacodynamics

Domperidone does not penetrate the blood-brain barrier well, so the use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism of dopamine receptors in the chemoreceptor trigger zone. Domperidone has no effect on gastric secretion.

Pharmacokinetics

Absorption After oral administration, it is quickly absorbed from the gastrointestinal tract. It has low bioavailability (about 15%). Reduced acidity of gastric contents reduces the absorption of domperidone. Cmax in plasma is reached after 1 hour. Distribution Domperidone is widely distributed in tissues; in brain tissue its concentration is low. Plasma protein binding is 91–93%. Metabolism Subject to intensive metabolism in the intestinal wall and liver. Excretion Excreted through the intestines (66%) and kidneys (33%), unchanged, 10 and 1% of the dose, respectively. T1/2 - 7–9 hours (with severe renal failure it is prolonged).

Use during pregnancy

Contraindications for use

Motilak is contraindicated in patients with established intolerance to the drug. Motilak should not be used when stimulation of the motor function of the stomach can be dangerous, i.e. with gastrointestinal bleeding, mechanical obstruction or perforation. Motilak is also contraindicated in patients with a prolactin-secreting tumor of the pituitary gland (prolactinoma).

Side effects

Side effects are rare. Exceptional cases of transient intestinal cramps have been reported. Extrapyramidal effects are rarely observed in children and are an exception in adults. These phenomena are completely reversible and disappear spontaneously after cessation of treatment. Since the pituitary gland is located outside the BBB, Motilac can induce an increase in plasma prolactin levels. In rare cases, this hyperprolactinemia can stimulate the appearance of galactorrhea and gynecomastia. Rare allergic reactions such as rash and hives have been reported.

Directions for use and doses

Inside, 15–20 minutes before meals. Adults in cases of acute nausea or vomiting: 20 mg 3-4 times a day and before bedtime. For chronic dyspeptic symptoms: 10 mg (1 tablet) 3-4 times a day and, if necessary, before bedtime. If necessary, the indicated dose is doubled. For patients with severe renal impairment, when re-prescribed, the frequency of administration should not exceed 1-2 times a day; it may be necessary to reduce the dose of the drug (depending on the severity of the deficiency).

Overdose

Symptoms: drowsiness, disorientation, extrapyramidal reactions (mainly in children). Treatment: in case of overdose, the use of activated carbon and careful observation are recommended. Anticholinergics, drugs used to treat parkinsonism, or antihistamines may be effective when extrapyramidal reactions occur.

Interactions with other drugs

Precautions for use

Given the metabolism of domperidone in the liver, Motilak should be prescribed with caution to patients with liver failure. In patients with severe renal failure (serum creatinine > 6 mg/100 ml, i.e. > 0.6 mmol/l), T1/2 of domperidone increased from 7.4 to 20.8 hours, but plasma concentrations of the drug were lower than in healthy volunteers. Since a very small percentage of the drug is excreted unchanged by the kidneys, single dose adjustment is unlikely to be necessary in patients with renal failure. However, when re-prescribed, the frequency of administration should be reduced to 1-2 times a day, depending on the severity of the deficiency, and it may also be necessary to reduce the dose. During long-term therapy, patients should be monitored regularly.

Special instructions for use

When using Motilac in combination with antacid or antisecretory drugs, the latter should be taken after meals and not before meals, i.e. they should not be taken at the same time as Motilac.