The drug "De-Nol" for pancreatitis is widely used due to its ability to restore damaged pancreatic tissue and increase the body's strength. Despite the high effectiveness of this medicine, when using it, you must remember about the possible occurrence of side effects. To avoid negative consequences and not complicate the course of the disease, before starting a treatment course you should consult a doctor and set the desired dosage.
Let's look at the instructions for use for the drug "De-Nol".
Reviews and price will be given at the end of the article.
General information
This is a potent drug that is used in the treatment of diseases of the pancreas and is prescribed simultaneously with medications such as Omez, Pancreatin and Drotaverine. The product is produced in white coated tablets. The drug, having an effect on the mucous membrane of the stomach, enhances its protective functions. Thanks to this process, the risk of ulcers due to gastritis with an increased concentration of hydrochloric acid, as well as the negative effects of various chemicals and toxins, is reduced.
"De-Nol" for chronic pancreatitis is also very effective.
When using this medicine, the blood supply to tissues improves, the production of pepsin decreases, restoration processes are stimulated, and metabolism within cells is normalized. The main feature of the drug is its bactericidal effect. But unlike many medications with a similar property, the drug in question does not cause resistance in bacteria. The active substances of the drug “De-Nol” for pancreatitis are not absorbed into the blood and are completely eliminated from the body.
The pharmacological agent "De-Nol" is prescribed for diseases that are accompanied by a high probability of developing inflammation in the gastric mucosa. Therefore, it is used for dyspepsia, chronic gastritis, and manifestations of irritable bowel. The advantage of this medicine is that it can be used by people of all ages.
Many people are wondering whether it is possible to take De-Nol for pancreatitis. Let's look at the answer to this question in our article.
Features of the drug
The medication is available in the form of white tablets coated with a protective coating. The manufacturer warns that the product has an ammonia odor. This phenomenon is due to its chemical composition. A specific odor does not indicate the unsuitability of the medicine. De-Nol tablets are packaged in factory-made protective blisters, which are packaged in white and yellow boxes with the logo of the manufacturing company Astellas.
The medicine has pronounced protective, antibacterial and healing properties. According to the clinical and pharmacological classification, De-Nol is effective for the treatment of peptic ulcers and gastroesophageal reflux disease.
The mechanism of action of the drug is based on the ability to bind proteins, forming a “barrier” on the surface of the mucous membrane. Under the influence of De-Nol, a protective film is formed on the damaged surface of the mucous membrane of the stomach or duodenum, which acts as a barrier to the acidic contents of the stomach. Thanks to these features, scarring of existing defects (erosions, ulcers) is accelerated.
The protective properties are based on stimulation of the synthesis of prostaglandin E2 (PGE2). When using De-Nol, the fastest possible therapeutic effect is achieved due to improved vascular circulation in the mucous membrane of the hollow organs of the gastrointestinal tract.
Recent studies have established the sensitivity of H. pylori to the antimicrobial action of bismuth. Helicobacter, in case of infection of the body, is considered the main factor in the development of ulcerative lesions. Bismuth subcitrate blocks the activity of intracellular enzymes of bacteria, which leads to their death.
Indications for use, according to the package insert from the manufacturer:
- ulcerative lesions of the stomach and/or duodenum;
- erosion of the hollow organs of the digestive tract;
- gastroenteropathy caused by chronic intoxication with alcohol and non-steroidal analgesics;
- gastritis, duodenitis, gastroduodenitis with various course options.
De-Nol for pancreatitis is used as an auxiliary drug. The drug is especially effective for the treatment of biliary pancreatitis. The medication is used to prevent functional disorders of the digestive tract, which often accompany diseases of the pancreas.
pharmachologic effect
This pharmaceutical product produces a bactericidal effect, relieves the manifestations of the inflammatory process and provides an astringent effect. The active elements of the drug “De-Nol” for pancreatitis, entering an acidic environment, contribute to the release of insoluble substances that settle on the gastric walls and create a kind of film. It must be taken into account that proteins and chelates attach exclusively to the affected areas of the mucous membrane. That is why after taking the drug there is no tissue irritation, and the process of regeneration of inflamed areas is significantly accelerated.
Drug analogues
De-Nol is a medicine produced by the Japanese pharmaceutical company Astellas. A number of analogues of the original drug are presented on the domestic pharmaceutical market. Analogs for the active component are domestic drugs Vis-Nol and Gastro-Norm. They contain a similar active ingredient. The features of the administration coincide with the original medicine De-Nol.
The price category of generics (from the English generic - derivative) is pleasantly different from the original De-Nol. All drugs on the pharmaceutical market have an effective therapeutic effect. However, the original pharmaceutical contains fewer impurities and is better tolerated by patients.
De-Nol is a medication with high therapeutic efficacy and minimal risk of side effects if the rules of use are followed. Taking the drug improves the regeneration of damaged tissues and suppresses the proliferation of pathogenic microorganisms. The product also activates the regeneration of pancreatic tissue.
Is it possible to take the drug for pancreatitis?
Treating pancreatitis with De-Nol without using other medications is not very effective. But taking this medicine is very important in the complex treatment of acute and chronic types of pancreatitis, as well as in the exacerbation phase of the disease.
This is due to the following factors:
- With exacerbation of chronic pancreatitis, the production of pancreatic enzymes increases. They can damage the mucous membrane of the gastrointestinal tract, causing the development of gastritis.
- Exacerbation of pancreatitis requires a “starvation” diet in the hospital for up to 5 days: patients do not eat food, which creates conditions for damage to the gastric mucosa.
- Chronic forms of pancreatitis are often associated with diseases of other parts of the gastrointestinal tract: gastroduodenitis, impaired bile outflow, disorder of motor-evacuation function;
- Pancreatitis can develop due to infection of the Helicobacter pylori gland.
Is it possible to use De-Nol as a prophylactic agent?
Gastritis and gastric ulcers have a chronic, often relapsing course. Periods of exacerbations are followed by remissions. More often, the deterioration of the health status of patients occurs in spring and autumn, which is associated with weakened immunity and massive hypo- and avitaminosis. Patients also note increased pain during emotional stress, heavy physical labor and deviations from the diet.
The prophylactic use of De-Nol can prevent the occurrence of an exacerbation of the disease. Persons suffering from ulcers and gastritis are recommended to take the drug in early autumn or spring, without waiting for their health to worsen. It has a moderate antacid effect and reduces the aggressive influence of factors from the external and internal environment of the body.
Scheme of medication use
How to take De-Nol for pancreatitis?
The described medication is prescribed for the treatment of the inflammatory process in the pancreas. The need for use is due to its ability to eliminate all kinds of gastrological problems, which in some cases accompany chronic forms of pathology.
Why does De-Nol help with pancreatitis?
The highest effectiveness is obtained with the combined treatment of biliary pancreatitis. It is recommended to take the drug for inflammation of the gland 4 times a day, 1 tablet, observing the same time intervals.
The De-Nol treatment regimen for pancreatitis must be strictly followed.
Children are given this medicine 2 tablets per day. The medication should be taken before meals, and after drinking juices, milk and other drinks, at least 30 minutes should pass. Otherwise, the effectiveness of the medicine is reduced. The duration of the therapeutic course is individual for each patient and can be 2 months.
Is De-Nol always allowed for pancreatitis?
Side effects
In cases of non-compliance with the dosages prescribed by the specialist for the use of De-Nol, undesirable effects may occur. The following adverse reactions are noted: vomiting, problems with stool, nausea. In rare situations, skin rashes may occur. Taking the medication in high dosages threatens the development of brain damage due to the accumulation of the main substance in the structures of the central nervous system.
Let's consider the compatibility of "De-Nol" with other medications.
De-Nol during pregnancy and lactation
Doctors unanimously prohibit pregnant and lactating women from taking De-Nol. The drug poses a particular danger to the fetus, starting from 5-6 weeks. It is during this period that the formation of all the systems and organs of the future baby occurs. The use of De-Nol during pregnancy can lead to spontaneous abortion, mutations and the occurrence of a number of congenital disabilities.
During lactation, the main substance of the drug, bismuth tripotassium dicitrate, passes into breast milk through the bloodstream. If it is consumed, a newborn may develop kidney and nervous system diseases.
In this regard, the use of De-Nol in pregnant women is strictly prohibited; when breastfeeding, taking the drug is possible only when the baby is transferred to artificial feeding.
Drug compatibility
For the treatment of pancreatitis, the drug "De-Nol" is prescribed. However, not all patients know that the effectiveness of this drug is significantly reduced if it is taken incorrectly. In this case, there is a possibility of developing complications that arise due to increased acidity. Since De-Nol tablets create a protective film on the gastric mucosa, the consumption of fruits, juices, and dairy products in some cases helps to reduce the effectiveness of the drug. Therefore, experts recommend maintaining time intervals between taking the medication and consuming the above products.
De-Nol should not be taken simultaneously with tetracyclines, since its active elements can slow down the penetration of antibacterial substances into the blood. When treating with the drug, the use of medications that contain bismuth is contraindicated. When the therapeutic course of the drug is completed, it is necessary to perform a laboratory blood test to determine the concentration of bismuth in the plasma. Despite the minimal number of contraindications to therapy with the drug "De-Nol", it can only be taken as prescribed by a specialist.
Special Recommendations
This medicine should not be used for more than 8 weeks. During therapy, it is not recommended to increase the established daily dosage, as there is a risk of overdose and side effects. At the end of treatment, the concentration of the active substance in the blood should not exceed 3-59 mcg/l, and intoxication is observed only when its concentration is more than 110 mcg/l. During the use of the pharmacological agent in question, it is possible that feces may turn dark due to the formation of bismuth sulfide. In some cases, there is a slight darkening of the surface of the tongue.
Patient opinions
There are a lot of reviews about this medication, which indicates its wide popularity among people suffering from diseases of the digestive organs. The drug "De-Nol" is prescribed not only to adults for pancreatitis. It is often used in the treatment of stomach diseases in young children. Parents note that the children’s condition quickly normalizes after taking the medication, pain and discomfort disappear.
As for the treatment of pancreatic inflammation, patients note the high effectiveness of the drug in question, its good tolerability, and the absence of side effects. If they occur, the symptoms are usually minor. According to consumer reviews, the medication normalizes the condition very quickly - within approximately two days when acute pathological conditions develop. In chronic forms, its effect is observed somewhat later - about a week after the start of treatment.
As disadvantages of the drug, patients note its high cost and the presence of heavy metal in its composition. Some people write that the drug did not have the expected effect.
We reviewed the instructions for use, reviews and price for the drug “De-Nol”.
