Finding the right and effective drug to get rid of peptic ulcers of the digestive system can sometimes be very difficult. This is why you should not self-medicate. It is necessary to consult a doctor for a full examination and prescription of optimal medications.
In this article we will look at a drug such as Ultop. Instructions, price, indications and contraindications for its use - all this information will be described in as much detail as possible. In addition, we will find out whether similar means exist.
General information about the drug "Ultop"
The product is available in capsule form. They can be sold in a blister or plastic bag. Depending on this, the shelf life of the medication will differ.
- 2 years for capsules of 10 mg and 40 mg in blister.
- 3 years for capsules 10 mg and 40 mg in a polyethylene case.
- 3 years for 20 mg capsules in a polyethylene case and blister.
The drug must be stored at temperatures up to 25 degrees in a dry place inaccessible to children. Do not use after expiration date!
The drug is dispensed in pharmacies with a prescription from a doctor.
Comparison of addiction between Ultop and Losek maps
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
Thus, the totality of the values of such parameters as “o syndrome” in Ultop is quite similar to the similar values in Losek maps. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Ultop the meaning of the “syndrome” is quite small, however, the same as in Losek maps.
Indications for use of "Ultopa"
The drug has a wide spectrum of action.
It is prescribed to patients with:
- gastroesophageal reflux disease;
- peptic ulcers of the stomach and duodenum;
- Zollinger-Ellison syndrome;
- reflux-like and ulcer-like symptoms.
In addition, "Ultop" can be used for dyspepsia, as well as as a prophylactic agent for possible ulcerative lesions of the duodenum and stomach, provoked by the use of non-steroidal anti-inflammatory drugs.
Side effects
Ultop can cause a number of side effects.
- In the digestive system: nausea, vomiting, diarrhea or constipation, flatulence. Less commonly, increased activity of liver enzymes, impaired taste perception, stomatitis, and dry mouth may occur.
- In some cases, thrombocytopenia, pancytopenia, leukopenia, and agranulocytosis may occur.
- From the nervous system: patients with somatic diseases may complain of headaches, dizziness, depression or states of severe agitation.
- In some cases, myalgia, myasthenia gravis, and arthralgia are observed.
- Sometimes the skin also suffers: exudative eczema multiforme, photosensitivity, and alopecia appear. Allergic reactions such as urticaria, rash, itching, bronchospasm, fever, anaphylactic shock and interstitial nephritis are also possible.
- Other side effects include increased sweating, blurred vision, general malaise, gynecomastia, and peripheral edema.
Precautionary measures
The active use of omeprazole-based drugs has led to the emergence of the term “omeprazole resistance” in the medical community. that some people are insensitive to the effects of the drug. When using the medicine in a standard dose, the acidity of gastric juice does not decrease in such patients, which is confirmed by pH measurements. It is assumed that the stomach cells of these patients have a different proton pump structure, and omeprazole molecules cannot contact them. But it is important to remember: true resistance to omeprazole is rare. Sometimes the lack of effect is due to other reasons - for example, taking the medicine incorrectly or using a generic drug of dubious quality.
Omeprazole, like other proton pump inhibitors, sometimes exhibits the overnight breakthrough phenomenon. Then at night, regardless of the drug taken, the acidity of the gastric juice increases. This condition lasts about an hour or more and reduces the effectiveness of therapy.
Treatment with omeprazole may lead to the development of undesirable reactions:
- nausea, constipation, abdominal pain;
- dizziness, headache;
- general weakness;
- kidney dysfunction;
- muscle and joint pain;
- allergic reactions.
Omeprazole and Ultop are prohibited for use in children and patients with chronic liver pathology. FDA also: Long-term use of the drug in high dosages increases the risk of hip, wrist and spine fractures. Several sharp decreases in blood magnesium levels have been described in elderly patients during therapy.
Omeprazole-based drugs are not recommended for use during lactation. The FDA has classified the drug as Category C. This means that animal testing has shown risks to the fetus, including possible birth defects. No studies have been conducted on humans. The drug is also not prescribed during lactation.
Features of use and overdose
Only a doctor can prescribe the use of Ultop! It is first necessary to exclude the presence of possible malignant processes. This must be done because treatment can mask the symptoms and making a correct diagnosis will be much more difficult.
The drug can be taken with food - this will in no way affect its effectiveness.
The required dose and frequency of taking the drug are prescribed by the doctor after the examination and diagnosis.
An overdose of Ultop can cause abdominal pain, diarrhea, headaches and dizziness, apathy, depression and confusion. In this case, symptomatic therapy is additionally carried out.
Comparison of ease of use of Ultop and Losek mapsa
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Ultop is approximately the same as Losek Maps. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-04 13:43:43
"Omeprazole": instructions, price
Let's start with the drug Omeprazole. It is produced in the form of capsules or lyophilisate for the preparation of a solution for intravenous administration, as well as infusion therapy.
The main indications for use of the drug are:
- the presence of a benign ulcer of the duodenum or stomach;
- during eradication therapy of Helicobacter pylori;
- as a preventive measure against aspiration of acidic gastric contents;
- to reduce the symptoms of dyspeptic disorders dependent on the level of acidity (for example, belching, heartburn, bloating, nausea, bad taste in the mouth, and so on);
- during gastroesophageal reflux disease (GERD);
- with gastritis with high acidity;
- for the treatment of chronic pancreatitis.
The main contraindications for use are children under 5 years of age (with the child weighing up to 20 kg), as well as the lactation period or the presence of hypersensitivity to the components of the drug.
The side effects of Omeprazole are the same as those of Ultop: nausea, vomiting, diarrhea, liver dysfunction, headaches, skin rashes, gynecomastia, and so on.
As a result of an overdose of the drug, drowsiness, confusion, headache, decreased visual perception, nausea, arrhythmia, tachycardia, and dry mouth may occur. To eliminate them, symptomatic therapy is carried out.
What will help you find out more detailed information about the drug Omeprazole? Instructions! The price of the product, by the way, is quite low and is within 112 rubles per package.
In pharmacies, Omeprazole is dispensed with a doctor's prescription.
Ultop
Ultop ®
(lat.
Ultop ®
) is an antiulcer drug, a proton pump inhibitor.
Composition of Ultop
Active ingredient
: omeprazole.
Excipients:
- sugar granules (sucrose, corn starch);
- hyprolose;
- magnesium carbonate heavy;
- sucrose;
- corn starch;
- sodium lauryl sulfate.
Dosage forms of Ultop
10 mg capsules:
two-color, capsule body - light pink, cap - white.
20 mg capsules:
two-color, capsule body - light pink, cap - brown-pink.
40 mg capsules:
two-color, capsule body - brown-pink, cap - light pink.
The contents of 10 and 40 mg capsules
are white to white pellets with a yellowish or pinkish tint.
The contents of 20 mg capsules
are white to slightly yellowish or slightly pinkish pellets.
Indications for use of Ultop
- peptic ulcer of the stomach and duodenum (acute phase and anti-relapse treatment), incl. associated with Helicobacter pylori
(as part of combination therapy); - reflux esophagitis;
- erosive and ulcerative lesions of the stomach and duodenum associated with taking NSAIDs, stress ulcers;
- Zollinger-Ellison syndrome.
Method of use of Ultop and dose
- Orally,
before meals, with a small amount of water (the contents of the capsule must not be chewed). - Duodenal ulcer in the acute phase
- 20 mg/day for 2-4 weeks (in resistant cases - up to 40 mg/day). - Gastric ulcer in the acute phase and erosive-ulcerative esophagitis
- 20-40 mg/day for 4-8 weeks. - Erosive and ulcerative lesions of the gastrointestinal tract caused by taking NSAIDs
- 20 mg/day for 4–8 weeks. - Eradication of Helicobacter pylori
- 20 mg 2 times a day for 7 or 14 days (depending on the treatment regimen used) in combination with antibacterial agents. - Anti-relapse treatment of gastric and duodenal ulcers
- 10–20 mg/day. - Anti-relapse treatment of reflux esophagitis
- 20 mg/day for a long time. Available upon request. - Zollinger-Ellison syndrome
- the dose is selected individually depending on the initial level of gastric secretion, usually starting from 60 mg/day. If necessary, the dose is increased to 80–120 mg/day, in which case it is divided into 2 doses. - In patients with severe liver failure, the daily dose should not exceed 20 mg.
The hydrosorbent capsule should not be swallowed!
Comparison of Ultop with other proton pump inhibitors
Among leading gastroenterologists, there are different points of view on the comparative effectiveness of specific types of proton pump inhibitors.
Some of them argue that, despite the differences that exist between PPIs, today there is no convincing data to make a conclusion about the greater effectiveness of any PPI compared to others (Vasiliev Yu.V. et al.). Many prominent gastroenterologists also believe that during eradication, the type of PPI included in triple (quadruple) therapy does not matter (Nikonov E.K., Alekseenko S.A.). Others write that, for example, esomeprazole is fundamentally different from the other four PPIs: omeprazole, pantoprazole, lansoprazole and rabeprazole (Lapina T.L., Demyanenko D., etc.). Still others believe that rabeprazole is the most effective (Ivashkin V.T. et al., Maev I.V. et al.). According to Bordin D.S., the effectiveness of all PPIs for long-term treatment of GERD is similar. In the early stages of therapy, lansoprazole has some advantages in the speed of onset of effect, which potentially increases patient adherence to treatment. If you need to take several drugs to simultaneously treat other diseases, pantoprazole is the safest.
There are many generic PPIs on the Russian market and the market of other CIS countries. Due to possible differences in the quality of drugs, an objective assessment of their clinical effectiveness is important. Currently, 24-hour monitoring of intragastric pH levels is an objective and accessible method for testing antisecretory agents (Alekseenko S.A.).
An important advantage of Ultop compared to original drugs, such as Losek MAPS, Nexium or Pareit, is its price. The cost of an original proton pump inhibitor for one course of therapy for an acid-dependent disease is several thousand rubles. The use of ultratop makes it possible to reduce the price of the course by almost an order of magnitude (Maev I.V. et al.).
Professional medical publications concerning the use of Ultop in the treatment of gastrointestinal diseases:
- Maev I.V., Vyuchnova E.S., Shchekina M.I. Experience of using OMEPRAZOLE ULTOP (“KRKA”, Slovenia) in patients with duodenal ulcer. MGMSU.
- Maev I.V. The place and significance of proton pump inhibitors in the modern treatment of peptic ulcer // Experimental and clinical gastroenterology. – 2003. – No. 3. – p. 12–13.
- Burkov S.G. Modern approaches to the treatment of acid-dependent diseases // Breast Cancer. – 2007. – Volume 15. – No. 6.
- Bondarenko O.Yu., Zakharova N.V., Ivashkin V.T., Lapina T.L., Maev I.V., Samsonov A.A., Simanenkov V.I. Dynamics of symptoms and endoscopic picture during standard therapy of GERD // RZHGGK. – 2005. – No. 1. – Volume XV. - With. 40–45.
- Kaysinova A.S. System of medical technologies for sanatorium-resort rehabilitation of patients with erosive and ulcerative esophagogastroduodenal diseases. Abstract of dissertation. Doctor of Medical Sciences, Perm State Research Institute, Pyatigorsk, 2013.
On the website gastroscan.ru
in the literature catalog there is a section
“Omeprazole”
, containing medical articles concerning the treatment of diseases of the gastrointestinal tract with omeprazole.
Ultop price
At its price, Ultop belongs to the middle category of omeprazoles present on the Russian pharmaceutical market. In the State Register of the Russian Federation of maximum selling prices of manufacturers for medicines included in the list of Essential and Essential Medicines as of November 11, 2010, the following prices for ultratop are indicated:
- Ultop produced by KRKA, Slovenia: production packaging 14 pcs. enteric capsules containing 10 mg of omeprazole - 67.07 rubles, 28 pieces/10 mg - 121.79 rubles, 14 pieces/20 mg - 109.12 rubles, 28 pieces/20 mg - 205.84 rub., 14 pcs./40 mg — 165.56 rub., 28 pcs./40 mg — 297.55 rub.
- Ultop produced by Krka-Rus LLC, Russia: 14 pcs./10 mg - 72.42 rubles. , 28 pcs./10 mg — 131.53 rub., 14 pcs./20 mg — 117.85 rub., 28 pcs./20 mg — 222.31 rub., 14 pcs./40 mg — 178.80 rub., 28 pcs./40 mg - 321.35 rub.
For comparison. In the same register, on the same day, the following maximum prices are given:
- Losek-MAPS (AstraZeneca AB, Sweden) 14 pcs./10 mg - 541.60 rubles, 14 pcs./20 mg - 849 rubles.
- Omez (Dr. Reddy's Laboratories Ltd., India) 14 pcs./20 mg - RUB 132.36
- Omeprazole, Omeprazole AKOS (JSC Sintez, Russia) 30 pcs./20 mg - 18.63 rub.
Pharmacokinetics of Ultop
Omeprazole is rapidly absorbed from the gastrointestinal tract, Cmax in plasma is reached after 0.5–1 hour. Bioavailability is 30–40%. Plasma protein binding is about 90%. Omeprazole is almost completely metabolized in the liver. It is an inhibitor of the CYP2C19 enzyme system. T½ - 0.5–1 hour. Excretion by the kidneys is 70–80% and with bile – 20–30%. In chronic renal failure, excretion decreases in proportion to the decrease in creatinine clearance. In elderly patients, excretion decreases and bioavailability increases. In case of liver failure, bioavailability is 100%, half-life is 3 hours (Instructions for use).
Pharmacodynamics of Ultop
The active substance of Ultop - omeprazole - blocks the proton pump - H+-K+-ATPase - in the parietal cells of the gastric mucosa and thereby inhibits the production of hydrochloric acid. This leads to a decrease in the level of acidity in the stomach. After a single oral dose of Ultop, the effect of omeprazole occurs within the first hour and continues throughout the day, the maximum effect is achieved after 2 hours. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains gastric acidity at a level of 3 pH for 17 hours. After stopping taking ultop, acid production of parietal cells is completely restored after 3–5 days (Instructions for use).
Contraindications when using Ultop
Hypersensitivity to the drug, childhood, pregnancy, lactation.
Carefully
- renal and/or liver failure.
Use of Ultop during pregnancy and lactation
The safety of use during pregnancy and lactation (breastfeeding) has not been studied. Therefore, it is not recommended to prescribe during pregnancy. If it is necessary to prescribe during lactation, breastfeeding should be stopped.
Side effects
In rare cases, the following, usually reversible, side effects may occur.
- From the digestive system:
diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbances, stomatitis, transient increase in the activity of liver enzymes in plasma; in patients with previous severe liver disease - hepatitis, liver dysfunction. - From the nervous system:
headache, dizziness, agitation, drowsiness, insomnia, paresthesia, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with previous severe liver disease - encephalopathy. - From the musculoskeletal system:
muscle weakness, myalgia, arthralgia. - From the hematopoietic system:
leukopenia, thrombocytopenia; in some cases - agranulocytosis, pancytopenia. - From the skin:
itching, skin rash; in some cases - photosensitivity, exudative erythema multiforme, alopecia. - Allergic reactions:
urticaria, angioedema, bronchospasm, interstitial nephritis, anaphylactic shock, fever. - Other:
blurred vision, peripheral edema, increased sweating, gynecomastia; rarely - the formation of gastric glandular cysts during long-term treatment, as a result of blocking the production of hydrochloric acid, is benign, reversible (Instructions for use).
Interaction of Ultop with other drugs
Long-term use of omeprazole at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to changes in their plasma concentrations.
There was no interaction with concomitantly taken antacids.
May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole reduces gastric acidity).
Being an inhibitor of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin, which in some cases may require a reduction in the doses of these drugs.
When taken simultaneously with clarithromycin, the blood concentrations of omeprazole and clarithromycin increase.
Ultop overdose
Symptoms
:
blurred vision, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia. There is no specific antidote. Treatment:
symptomatic.
Nosological classification (ICD-10)
- K21.0 Gastroesophageal reflux with esophagitis
- K25 Stomach ulcer
- K26 Duodenal ulcer
- K27 Peptic ulcer of unspecified location
- E16. Zollinger-Ellison syndrome
- Y45 Analgesic, antipyretic and anti-inflammatory drugs
Special instructions when using Ultop
- Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), because Treatment, masking symptoms, can delay the correct diagnosis.
- In special cases, if you have difficulty swallowing a whole capsule, you can swallow its contents after opening or dissolving the capsule, and you can also mix the contents of the capsule with a slightly acidified liquid (juice, yogurt) and use the resulting suspension for 30 minutes.
- In normal dosages, the drug does not affect the speed of psychomotor reactions and concentration.
general information
According to the pharmacological index, Ultop belongs to the group “
Proton pump inhibitors
”
. For ATC - to the group “Proton pump inhibitors”, code A02BC01.
The manufacturer of Ultop is KRKA, Slovenia.
Instructions for use of the drug Ultop (enteric capsules, 10 and 40 mg). Changes No. 1 of 08/01/2011 to the Instructions for use of the medicinal product Ultop (enteric capsules, 10 and 40 mg).
Ultop 10 mg capsules are available from pharmacies without a prescription, other dosage forms are available by prescription.
Other medicines containing the active ingredient omeprazole:
The following drugs are (were) registered in Russia: Bioprazole, Vero-Omeprazole, Gastrozol, Demeprazole, Zhelkizol, Zerotsid, Zolser, Chrismel, Lomak, Losek, Losek MAPS, Omegast, Omez, Omez Insta, Omecaps, Omepar, Omeprazole, Omeprazole pellets . , Pepticum, Pleom-20, Promez, Risek, Romesek, Sopral, Ulzol, Ulkozol, Ultop, Helitsid, Helol, Cisagast.
On the pharmaceutical markets of the countries of the former republics of the USSR, a number of drugs with the active substance omeprazole are presented, which are not registered in Russia, in particular: Gasek (Mepha Lda, Switzerland), Losid (Flamingo Pharmaceutical, India), Omeprazole-Astrapharm (TOV Astrapharm, Ukraine ), Omeprazole-Darnitsa (JSC Pharmaceutical Company Darnitsa, Ukraine), Omeprazole-KMP (JSC Kievmedpreparat, Ukraine), Omeprazole-Lugal (Lugansk Chemical Pharmaceutical Plant, Ukraine), Tserol (Neon Antibiotics Private Limited, India) and others.
Branded medicine with the active ingredient omeprazole on the market in the USA and a number of other countries Prilosec (formerly called Losec). An over-the-counter option is Prilosec OTC.
Ultop has contraindications, side effects and application features; consultation with a specialist is necessary.
Back to section
"Losek"
We continue to consider analogues of the drug “Ultop”. The next remedy we will focus on is Losek. Its price is significantly higher in comparison with the previous drug.
Losek is available in tablet form and can be prescribed for:
- the presence of peptic ulcers of the duodenum and stomach;
- stomach diseases caused by Helicobacter pylori;
- Zollinger-Ellison syndrome;
- acid-dependent dyspepsia.
The only contraindication for use is the presence of an allergy to its components.
No cases of drug overdose were found, therefore there is no need for any specific therapy while taking it.
The side effects remain the same as in the two previous cases, so we will not repeat them.
What is the cost of the drug Losek? The price is within 380 rubles and depends on the region of residence.
The drug is dispensed as prescribed by a doctor.
Comparison of side effects of Ultop and Losek mapsa
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Ultop's side effects are almost the same as Losek's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Ultop is similar to Losek Maps: how quickly the body recovers after taking it and whether it recovers at all.
"Gastrozol"
Next in line is the drug Gastrozol. The instructions for use say that its main active substance is omeprazole and the product is available in capsule form.
"Gastrozol" is an antiulcer drug, so it is prescribed for:
- presence of reflux esophagitis;
- peptic ulcers of the gastrointestinal tract;
- gastrointestinal pain with increased acid secretion;
- nonsteroidal gastropathy resulting from taking nonsteroidal anti-inflammatory drugs.
In addition, the product is used to get rid of the bacterium Helicobacter pylori (as a component in complex treatment).
Are there any contraindications to the use of the drug "Gastrozol"? The instructions for use highlight the following cases when the use of the medication is strictly prohibited:
- During pregnancy and breastfeeding;
- infancy and childhood;
- the presence of hypersensitivity to the components of the drug.
Also, doctors should be especially careful when prescribing Gastrozol to patients with liver or kidney pathology.
An overdose of the drug may be accompanied by dry mouth, confusion, arrhythmia, tachycardia, drowsiness, nausea, vomiting, headaches, blurred vision. In this case, there is a need for symptomatic therapy.
Possible side effects are similar to those that Ultop has.
Assessing the effectiveness of drugs
There is still no consensus in the medical community which drug is best to use for peptic ulcers. For example, Vasiliev V.V., that today there is no convincing evidence that one PPI is better than another. In his article, he writes that any drug from this group can be used - the main thing is to combine proton pump inhibitors with antibacterial agents. A number of other gastroenterologists believe this theory and believe that the choice of PPI does not matter.
Other researchers have noted that not all proton pump inhibitors are equally effective. This applies not only to various medications, but also to generics of the same drug. Therefore, many gastroenterologists carry out control daily monitoring of the pH level of gastric juice. Clinical studies are being conducted on this issue. It is likely that in the future we will be able to get a definitive answer to the question of which proton pump inhibitor does its job better.
A comparative study of two PPIs, Ultop and Omeprazole, has not been conducted. But in the medical literature there is data on the pharmacodynamics and therapeutic effect of each drug separately. Thus, Ultop is the drug of choice in the complex treatment of gastric and duodenal ulcers. A. A. Stepchenko and co-authors in the review state: Ultop as part of eradication therapy has proven itself to be the most effective and economically advantageous remedy. In another, scientists have proven that Ultop’s therapeutic effect is practically not inferior to the original drug.
We also analyzed information about proton pump inhibitors and found out that drugs in this group suppress the production of gastric juice faster and more effectively. They are superior to H2 blockers and other drugs traditionally used in the treatment of peptic ulcers. Extensive evidence of the effectiveness of PPIs in the Cochrane Library.
"Omezol"
Let's continue to consider analogues of Ultop, one of which is Omezol. The product is available in capsule form. The main active substance is omeprazole.
The drug is used to treat peptic ulcers of the stomach and duodenum during exacerbation. In addition, it is recommended for use in reflux esophagitis, Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract and other diseases of the esophagus.
As for the side effects of the drug "Omezol", reviews from doctors claim that there are not so many of them. They can manifest themselves in the form of abdominal pain, nausea, diarrhea, flatulence, dizziness and headache, rash or general weakness.
The product is not recommended for pregnant, nursing mothers and children.
Before using the drug, you should consult a doctor, since when prescribing the required daily dosage, not only the nature of the disease, but also the individual characteristics of the patient’s body are taken into account.
How proton pump inhibitors suppress stomach acid production
All proton pump inhibitors work according to the same scheme:
- Suppress the action of the enzyme H+-K+-ATPase in the parietal cells of the stomach.
- They block the synthesis of hydrochloric acid at the final stage.
- Reduce the level of basal secretion of gastric juice.
- Reduces stomach acidity.
- Prevents damage to the mucous membrane of the stomach and duodenum and the appearance of ulcerative defects.
At the same time, the impact of the aggressive environment of the stomach on the esophagus is reduced. Therefore, proton pump inhibitors are used not only for peptic ulcers, but also in other situations where it is necessary to reduce the acidity of gastric juice - for example, with reflux esophagitis. With this pathology, hydrochloric acid enters the esophagus, causing heartburn and destroying the mucous membrane. If you reduce the production of gastric juice, the patient's condition will improve.
Omeprazole also affects Helicobacter pylori. This bacterium lives in the pylorus of the stomach and duodenum and causes ulcers on the mucous membrane. Helicobacteriosis is also associated with the development of stomach cancer. Omeprazole is not an antibiotic, but it has a nonspecific bactericidal effect. In the instructions for the drugs: PPIs in combination with antibiotics help get rid of the bacteria and achieve remission of peptic ulcer disease. During treatment, unpleasant symptoms go away, the mucous membrane of the digestive tract heals and the risk of complications (gastrointestinal bleeding, stomach cancer) decreases.
What else you need to know about proton pump inhibitors:
- PPIs block enzyme production and hydrochloric acid synthesis almost irreversibly and for a long time. In order for gastric juice to begin to be synthesized again, new proton pumps must form in the parietal cells of the stomach. Therefore, Omeprazole and Ultop act longer than they actually remain in the body. The positive effect of the drugs persists even after they are completely removed.
- PPIs are quickly destroyed in the acidic environment of the stomach. Therefore, such products are not available in tablets or suspensions. For oral administration, capsules coated with a durable acid-resistant coating are used. The protective film dissolves only in the intestines, where there is no hydrochloric acid.
- Clinical trials: omeprazole, when taken orally, is rapidly absorbed from the intestine. After the membrane is destroyed, it enters the blood and reaches the parietal cells of the stomach. There it binds to the enzyme and blocks the synthesis of hydrochloric acid. It undergoes transformation in the liver and is excreted primarily by the kidneys. In people with chronic liver disease, the release of the drug slows down.
"Crismel"
Let’s finish looking at analogs of “Ultop” with the drug “Crismel”. It is produced in the form of capsules with omeprazole as the main active substance.
In what cases is it possible to use the drug "Crismel"? The instructions for use say that it is prescribed if:
- gastroesophageal reflux (including with esophagitis);
- gastrojejunal ulcer;
- peptic ulcer;
- esophagitis;
- ulcers of the esophagus, duodenum, stomach;
- for other diseases of the esophagus.
Side effects can be expressed in the form of headaches and dizziness, weakness, nausea, abdominal pain, diarrhea, allergic reactions in the form of a rash.
The product is prohibited for use by children, as well as women during pregnancy and breastfeeding.
All analogues of Ultop (Crismel, of course, including) can be used only after consulting a doctor and excluding the presence of possible malignant processes in the digestive system.
Comparison of the effectiveness of Ultop and Losek mapsa
Ultop is more effective than Losek mapsa - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Ultop is more pronounced, then it is impossible to achieve this effect with Losek mapsa even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Ultop and Losek maps are also different, as is bioavailability - the amount of the drug reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
