Hemorrhoids are a common disease that causes a lot of unpleasant symptoms. Many patients believe that pathology is treated exclusively with drugs in the form of creams, ointments and enemas, but this is far from the case. Therapy of varicose veins of the rectum requires the use of oral agents that have a venotonic, angioprotective, and analgesic effect. Such medications include Detralex tablets for hemorrhoids. The drug has a beneficial effect on blood vessels, relieves itching, inflammation, swelling and pain. Use Reviews of Detralex for hemorrhoids indicate the effectiveness and safety of the drug. Despite this, it is recommended to use the medicine as prescribed by a doctor.
Compound
Detralex contains 500 mg of micronized flavonoid fraction (Purified micronized flavonoid fraction), in which diosmin is 90% (450 mg), hesperidin is 10% (50 mg).
Auxiliary components: gelatin, magnesium stearate, MCC, sodium carboxymethyl starch, talc, purified water.
Film shell composition: macrogol 6000, sodium lauryl sulfate, orange-pink premix for p/o (magnesium stearate, glycerol, hypromellose, iron dyes - yellow and red oxides, titanium dioxide).
Pharmacodynamics and pharmacokinetics
It has an angioprotective and venotonic effect, reduces venostasis , venous distensibility and capillary permeability, increases the tone of the venous walls, improves microcirculation and lymphatic drainage. Increases the ability of capillaries to maintain the integrity of the walls under mechanical stress.
The use of the drug Detralex helps to reduce the interaction of leukocytes and endothelium , as well as the adhesion of leukocytes in post-capillary venules, which reduces the severity of the damaging effect of inflammatory mediators on the venous valve leaflets and venous walls.
T½ - 11 o'clock. Excretion of active components is carried out mainly through the intestines. About 14% of the dose taken is excreted by the kidneys.
Pharmacodynamics
The pharmaceutical product belongs to the group of bioflavonoids. These are agents that significantly reduce the permeability of capillary walls. The active components penetrate the venous cavity and tone the walls of blood vessels. At the same time, the elasticity of the veins increases, reducing extensibility, and stagnation of venous blood is eliminated.
The fragility of capillaries is sharply reduced, and their resistance increases.
The studies carried out showed. That the optimal effect of the drug occurs when taking 1000 mg per day, in a single dose. The active substances quickly increase venous tone, their emptying occurs more quickly, due to which the walls become stronger and more elastic.
Severe pathologies of blood flow in the lower extremities are recommended to be treated with the drug Detralex, the price of which is affordable for everyone. It has been proven to increase capillary resistance. This helps in the fight even against chronic diseases of the veins of the lower extremities and in case of hemorrhoids.
The pronounced symptoms of the disease become less noticeable and bother the patient much less.
Once in the human body, the drug begins to quickly ferment and be processed, distributing the active substances. Scientists report that the half-life of the substances is about eleven hours. Most of the drug is excreted naturally in the feces, a little more than 10% is excreted in the urine.
Indications for use of Detralex
When are vein pills prescribed?
Indications for the use of Detralex are organic and functional venolymphatic insufficiency of the lower extremities , which is manifested by swelling and pain, a feeling of heaviness in the legs, trophic disorders, and convulsions.
When is the drug used as a pill for hemorrhoids?
The use of the drug Detralex is indicated for the symptomatic treatment of acute hemorrhoidal attack .
Additionally
For both varicose veins and hemorrhoids the drug is used as a symptomatic remedy and often as part of complex therapy.
To reduce the severity of symptoms of venous insufficiency, a venotonic ointment or gel can be prescribed along with tablets.
In the treatment of hemorrhoids Relief , Proctosan , Nigepan , etc.) and ointments ( Ichthyol , Hepatrombin , Bezornil , etc.) can be used to relieve pain and inflammation, improve vascular tone, reduce thrombosis and stop bleeding
Package
Each package of tablets includes instructions for Detralex, the price of which varies within a thousand rubles. A detailed plan for taking and storing tablets from the manufacturer is required in the packaging of the pharmacy product.
Each cardboard box contains three or six blisters with the same number of tablets. There are ten of them in each blister. There is a package containing two aluminum-coated PVC blisters containing nine pale yellow tablets.
Each cardboard pack contains the number of blisters indicated on the box and instructions for use of the drug from the manufacturer.
Side effects
Side effects of Detralex are extremely rare. Most often the body reacts to treatment with dyspeptic disorders ( nausea , diarrhea , etc.), sometimes neurovegetative disorders (malaise, headache , dizziness , etc.) and disorders of the subcutaneous tissue and skin ( urticaria , skin rashes) , itching).
In extremely rare cases, angioedema .
Detralex tablets, instructions for use
Instructions for use of Detralex for varicose veins
For venolymphatic insufficiency, the recommended dose is 2 tablets. 500 g per day. The tablets are taken with meals, one in the daytime, the second in the evening.
The medicine is prescribed only to adult patients. To enhance the effect, the doctor may also recommend using external therapy - ointment or gel.
The duration of treatment with Detralex for varicose veins , as well as the need for repeated courses, is determined by the doctor.
Detralex for hemorrhoids. How long to take pills for hemorrhoids?
The description attached to the drug on how to take Detralex for hemorrhoids states that in the acute stage of the disease (during an acute hemorrhoidal attack ) it is necessary to take 6 tablets per day. during the first 4 days of treatment and 4 tablets/day. in the next 3 days. Take the medicine with meals, dividing the daily dose into 2-3 doses.
Treatment of chronic hemorrhoids involves taking 4 tablets daily. They are taken with meals, 2 at each dose. After 7 days, you can reduce the dose by half and reduce the frequency of applications to 1 r./day.
How long to take the medicine depends on the degree of advanced disease and the effectiveness of therapy. On average, doctors for chronic hemorrhoids recommend taking pills in courses lasting 2-3 months. In case of an acute attack, treatment is carried out in short courses lasting 7 days.
If symptoms persist longer than this time, the patient should be examined by a proctologist.
Reviews of Detralex for hemorrhoids are mostly good. The main disadvantage of the drug, according to consumers, is its high price. However, given that Detralex is a drug with proven effectiveness (patients often notice an improvement in the situation after 2-3 days of taking the tablets), many people still prefer it over cheaper analogues.
Reviews
The drug is a new generation substance. This is a relatively new method of treating venous pathologies, which has become widely used by patients with a similar problem.
Reviews for Detralex are almost unanimously positive, with a lot of praise from satisfied patients.
For many years I worked in production, where I had to constantly sit in an unchanged position. This had a negative impact on the condition of my legs, and serious varicose veins appeared. Phlebologists and other doctors were already throwing up their hands and suggesting surgical intervention. I did not dare to do this, because I am very afraid of such manipulations. But the drug Detralex, which was prescribed to me by the doctor, worked wonders. The veins began to gradually return to normal. There is still a long way to go to a perfect cure for the pathology, but I feel much lighter. The constant pain and heaviness in my legs have disappeared; in the morning I don’t want to lie down longer so as not to feel pain again. I'm happy with the therapy.
Anna Borisovna, 62 years old
I spend a lot of time on my feet, playing sports and taking long walks. I know how important this is for human health and I try not to miss training. But at the same time, I was surprised to notice that my legs began to be covered with a thin venous mesh. Mistaking this for age-related changes, she nevertheless did not put up with this state of affairs and went to a phlebologist. The diagnosis of varicose veins struck me in the heart. But I'm not used to giving up. The doctor prescribed a course of treatment with Detralex, which I readily comply with. I can note that the symptoms of varicose veins have noticeably subsided, the enlarged veins on the calves and thighs have disappeared. I am pleased with the result and with my beautiful legs, which I am proud of.
Valeria S., 45 years old
For many years I suffered from the appearance of hemorrhoids. Consultations with a proctologist and regular courses of treatment helped little. I lived with constant pain and lack of comfort, as a result of which my quality of life dropped significantly. Another trip to the doctor resulted in the prescription of Detralex tablets. At first I was too skeptical about them and did not believe in the therapeutic effect, but the result I saw pleased me. The symptoms of hemorrhoids have practically disappeared, and finally I can move around and sit without pain.
Vyacheslav P., 52 years old
special instructions
The use of tablets during an acute hemorrhoidal attack cannot replace specific therapy and creates obstacles to the treatment of other proctological diseases.
If after a short time there is no rapid decrease in the severity of symptoms, the patient should be examined by a proctologist, and the doctor should reconsider the therapy.
For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:
- avoid standing for long periods of time and prolonged exposure to the sun;
- adjust body weight and diet;
- wear compression stockings to improve blood circulation;
- hike.
Detralex's analogs
Level 4 ATX code matches:
Rutin
Venosmin
Indovazin
Venoruton
Troxevasin Neo
Troxevasin
Ginkor Gel
Ginkor fort
Vasocket
Anavenol
Troxerutin
Askorutin
Antistax
Phlebodia 600
Venarus
What can replace the drug?
Drugs similar to Detralex with a similar mechanism of action, but a different composition:
- Antistax
- Askorutin
- Vasocket
- Venolek
- Venoruton
- Rutin
- Troxevasin
- Troxerutin
- Phlebodia 600
- Yuglanex
- Phlebofa
Substitutes based on Hesperidine + Diosmin:
- Venozol
- Venarus
The medicine and its analogues are used to treat functional and organic venous insufficiency , as well as hemorrhoids (both acute and chronic).
The price of Detralex analogues is from 60 rubles. The cheapest analogues of Detralex are the drugs Rutin and Ascorutin .
In Ukraine, if Detralex is not available in the pharmacy, they may offer to replace it with the following drugs:
- Venorin
- Venosmin
- Juantal
- Dioflan
- Normoven
- Nostalex
Which is better: Detralex or Phlebodia 600?
On forums, the drug is often compared with its analogues. And most often with the drug Phlebodia 600 . The basis of both products is diosmin. Its concentration in Phlebodia is 600 - 600 mg/tab., in Detralex - 450 mg/tab., however, in the latter its effect is enhanced by the presence of hesperidin (50 mg/tab.).
For varicose veins , take Phlebodia 600 1 tablet per day, Detralex - 2 tablets per day, that is, the daily dose of diosmin in the first case is 600 mg, in the second - 900 mg.
If we compare the pharmaceutical effect of the drugs and the specifics of their use, there are practically no differences.
However, thanks to the use of a unique technology for processing the active substance in its production, Detralex is absorbed into the body faster and more completely than its analogue, while its concentration in the blood plasma reaches a maximum after three to four hours.
Which is better: Detralex or Antistax?
Antistax is a herbal medicine that is used for venous circulation disorders. The capsules are based on a dried extract of red grape leaves with a high content of isoquercetin and quercetin glucuronide - flavonoids that help stabilize cell membranes, normalize vascular permeability, and reduce swelling.
However, if the effectiveness of Detralex was confirmed during clinical experiments, there is currently no scientific confirmation of the effectiveness of Antistax.
Another difference between the drugs is that Detralex can be used during pregnancy, but there is no information regarding the safety and effectiveness of Antistax for pregnant women.
According to experts, Antistax for vascular diseases can be recommended more as a prophylactic agent and as an addition to the main treatment.
Thrombovazim or Detralex - which is better?
Thrombovazim is an enzyme preparation with thrombolytic, cardioprotective and anti-inflammatory activity. Its active ingredient is a complex of proteinases produced by Bacillus subtilis.
The medicine is prescribed as part of complex therapy for chronic venous insufficiency . It is strictly contraindicated for peptic ulcers , pregnancy and breastfeeding.
Considering that the drugs Detralex and Trombovazim have different pharmacological effects, it is not correct to compare them. Especially if you take into account that doctors often recommend taking them in combination.
Which is better: Detralex or Venarus?
Venarus is a Russian analogue of the drug. If you compare which is better - Detralex or Venarus, then you can come to the conclusion that there is no fundamental difference between them.
The basis of both drugs are the substances diosmin and hesperidin; the products differ only slightly in the composition of the auxiliary components. The principle of action of Venarus is the same as that of its analogue, and the drug is prescribed for the same thing as Detralex tablets.
Recommendations on how to take both remedies for varicose veins and hemorrhoids are also identical.
The annotations for the drugs are distinguished by the fact that an additional contraindication to the use of Venarus is the lactation period. In addition, the cheaper analogue of Detralex is characterized by lower bioavailability and is somewhat more likely to cause side effects than the drug produced by Les Laboratoires Servier.
List of used literature
- The use of Detralex in the treatment of acute and chronic hemorrhoids, scientific article authored by Ratmanov A.M., Mikhailova N.A., Filosofov S.Yu., Burtsev V.V. and Afanasyeva D.V.;
- Modern chronic diseases of the veins of the lower extremities: focus on transdermal phlebotropic drugs. Authors Bogachev V.Yu., Boldin B.V., Turkin P.Yu.;
- The use of Detralex and Preductal in the complex treatment of diabetic retinopathy. Author: Bahratova Yu.V.;
- The effectiveness of Detralex in the conservative treatment of pelvic varicose veins in women. Author: Moses V.G.;
- Phlebeurysm. Injuries that may avoid surgery. Author – Abramovich O.D.
Alcohol compatibility
There is no categorical ban on drinking alcohol during treatment with Detralex. The active ingredients of the drug are flavonoids hesperidin and diosmin, which, according to Wikipedia, are plant pigments and powerful natural antioxidants, do not interact with other substances and have no significant side effects.
However, it should be taken into account that, by affecting the cardiovascular system, alcoholic drinks provoke an increase in blood pressure and dilation of blood vessels, and a sharp influx of blood causes an increase in its stagnation in places of accumulation.
Thus, alcohol reduces the effectiveness of therapy and contributes to the progression of the disease.
Detralex during pregnancy
Despite the fact that studies have not revealed the teratogenic properties of Detralex, it is used with caution during pregnancy.
Due to the lack of information on the ability of diosmin and hesperidin to pass into breast milk during breastfeeding, the use of the drug should be avoided.
The category of effect on the fetus according to the FDA classification has not been determined.
Studies on rats have shown that the drug does not have reproductive toxicity.
Reviews of Detralex during pregnancy allow us to conclude that the drug really helps with problems with veins and hemorrhoids . With the use of tablets, pain in the legs disappears, the legs become less tired and do not swell (and if they swell, then not so much), the development of varicose veins hemorrhoids disappear (or are significantly reduced) .
Question answer
The drug has a number of indications for use. Among them:
- pain in the lower extremities and other organs, where there is a decrease in vascular tone;
- leg cramps;
- a feeling of heaviness and fullness during the day in the lower half of the body;
- constant “fatigue” of the legs;
- severe swelling of the limbs;
- trophic ulcers that appear on the skin;
- venous trophic ulcers.
In addition, the drug is widely used in the treatment of hemorrhoids, chronic or acute.
Only the attending physician can answer this question. You cannot self-medicate, even with over-the-counter medications. We advise you to contact the clinic, the doctor who is observing you, and clarify the drug treatment regimen, taking into account the addition of the substance Detralex.
The smallest cardboard package contains 18 tablets, which are enough to cure the acute phase of hemorrhoids and relieve the symptoms of the disease. For long-term treatment regimens, large packages of the drug are used, containing 30 and 60 tablets, respectively.
It is recommended to take the tablets in the morning, combining them with meals. If there is an acute phase of the disease, three tablets per day are prescribed, each of which is combined with food.
The manufacturer, in the instructions for use of the substance attached to the medicine, clearly described the components. None of them are gluten free.
Detralex tablets are a modern, well-absorbed drug that has proven its effectiveness in the treatment of venous pathologies and hemorrhoids. It is widely used by qualified doctors when prescribing treatment regimens for their patients.
Reviews of Detralex
On the forums you can find a variety of (and often completely opposite) reviews about Detralex tablets on the forums you can find different ones. But still, most patients respond well to the drug.
If you take pills for hemorrhoids , the result becomes noticeable already on the 2-3rd day of treatment. Moreover, the medicine “works” even in advanced cases (including during pregnancy, when almost all drugs are contraindicated, and surgical intervention is simply unacceptable).
If you take pills for varicose veins , the effect develops somewhat more slowly, but the achieved result can significantly improve the quality of life. Analyzing doctors' reviews about Detralex, we can come to the conclusion that the drug is effective, but:
- the result is more noticeable the earlier treatment is started (reviews of Detralex for varicose veins indicate that if you start taking pills when the first signs of the disease appear, you can forget about it (the disease) for many years);
- the effect develops gradually, that is, if the doctor said that the medicine should be taken for 2 months, then it really needs to be taken for the specified amount of time, and to maintain the achieved results, repeat the course 1-2 times a year;
- the approach to treatment must be comprehensive - in order to achieve the desired effect, do not forget about the regimen, diet, adequate physical activity, and the use of other medications.
Side effects from the use of tablets develop extremely rarely, and they do not require special treatment or discontinuation of Detralex. This effect is due to the unique medicinal formula of the drug and a special production technology: the particles of the active components of Detralex are so small that they are very easily absorbed by the body (due to its high bioavailability, the drug is considered more effective than its more inexpensive analogues).
Detralex price, how much it costs
Detralex 500 mg tablets in Russia sell for an average of 800 rubles. for package No. 30 and 1500 rubles. per package No. 60.
The average price of Detralex tablets for hemorrhoids and varicose veins in Ukraine (for 60 tablets 500 mg) is about 300 UAH.
The drug is available exclusively in the form of tablets and suspension. You won’t be able to find Detralex ointment or lyophilisate.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Detralex tablets p.p.o.
1000 mg 30 pcs. LLC Servier Rus 1658 rub. order - Detralex tablets p.p.o. 1000 mg 60 pcs. Servier Rus LLC
RUB 2976 order
- Detralex tablets p.p.o. 500 mg 60 pcs. Servier Rus LLC
RUB 1,868 order
- Detralex tablets p.p.o. 500 mg 30 pcs. Servier Rus LLC
RUR 978 order
- Detralex tablets p.p.o. 1000 mg 18 pcs. Servier Rus LLC
RUB 1,034 order
Pharmacy Dialogue
- Detralex (tab.p.pl.vol. 1000 mg No. 30) Serdix/Servier Rus LLC
RUB 1,933 order
- Detralex (tab.pl.vol.1000mg No. 60)Servier
RUB 3,345 order
- Detralex tablets 1000 mg No. 18 Serdix LLC
1050 rub. order
- Detralex tablets 500 mg No. 60Servier
RUB 1,837 order
- Detralex tablets 500 mg No. 30Servier
938 rub. order
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Pharmacy24
- Detralex 500 mg N60 tablets Lab.Serv e Industries, France
271 UAH order
PaniPharmacy
- Detralex tablets Detralex tablets. p/o No. 60 France, Servier Industrie
309 UAH. order
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Pregnancy and lactation
The instructions for Detralex tablets and oral suspension do not prohibit the use of the drug in patients who are pregnant. Research by scientists was carried out on animals; during them, no deterioration in the well-being of the experimental subjects was revealed.
As part of the use of the drug by pregnant women, during the use of the substance, no side effects were identified specifically in pregnant women. However, with lactation the situation is slightly different.
Scientists have not yet been able to find out whether the drug is excreted through the breast milk of a nursing mother. In this regard, it is recommended that women who are breastfeeding not take Detralex. If it is not possible to do without therapy, lactation is stopped during treatment.
