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Instructions for use LINEX® (LINEX®)

A drug of biological origin that regulates the balance of intestinal microflora. Normalizes intestinal microflora. Maintains and regulates the physiological balance of intestinal microflora (microbiocenosis), ensures its physiological functions in the intestine.

Bacteria in the composition of Linex® restore the disturbed balance of intestinal microflora due to dysbacteriosis.

Live lactic acid lyophilized bacteria that are part of the drug are an integral part of the normal intestinal microflora, maintain and regulate the physiological balance of microbiocenosis in all parts of the intestine, and have pronounced antagonistic properties against pathogenic and conditionally pathogenic flora. They participate in the synthesis of vitamins B1, B2, B6, B12 (in nature they are synthesized only by microorganisms), PP, K and E, folic and ascorbic acids, provide the body with biotin, and have immunostimulating properties. By producing lactic acid and reducing the pH of the intestinal contents, the microorganisms used create favorable conditions for the absorption of iron, calcium, and vitamin D. Lactic acid bacteria carry out the enzymatic breakdown of proteins, fats and complex carbohydrates (including in lactase deficiency in children) that are not absorbed into the body. In the small intestine, carbohydrates and proteins undergo deeper breakdown in the large intestine by anaerobes (including bifidobacteria). The bacteria included in the drug facilitate the digestion of proteins in infants (phosphoprotein phosphatase of bifidobacteria is involved in the metabolism of milk casein); participate in the metabolism of bile acids (formation of stercobilin, coprosterol, deoxycholic and lithocholic acids; promote the reabsorption of bile acids).

Taking into account the peculiarities of the distribution of microflora throughout the human gastrointestinal tract - the predominance of lactobacilli and lactic acid streptococcus in the small intestine, and bifidobacteria in the large intestine, Linex® ensures the supply of “medicinal” microflora in quantitatively and qualitatively balanced proportions.

The antagonistic properties of Linex® are associated with the ability of its constituent microorganisms to produce lactic and, to a lesser extent, acetic and propionic acids. The created acidic environment (pH of the intestinal contents approaches 4-5.8) is unfavorable for the development of pathogenic and opportunistic microorganisms.

Linex® forte capsules contain Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). Both strains of lactic acid bacteria are normal representatives of the human intestinal microflora. There are several potent mechanisms by which strains LA-5 and BB-12 exert their characteristic protective and therapeutic effects.

They inhibit the growth of pathogenic bacteria by:

decrease in pH in the gastrointestinal tract (as a result of the ability of LA-5 to produce lactic acid, and BB-12, in addition to lactic acid, also produce acetic and succinic acids);
production of metabolites toxic to pathogenic bacteria (H2O2 production);
production of antibacterial substances, bacterions (LA-5 produces acidocin, which is a broad-spectrum bacteriocin that inhibits the growth of bacteria and fungi);
competition with pathogenic bacteria for nutrients;
blocking adhesive receptors, which prevents the colonization of other, potentially pathogenic microorganisms.

They also stimulate specific and non-specific parts of the immune system.

Disturbances in the balance of the intestinal microflora (for example, with viral and bacterial gastrointestinal infections, with the use of broad-spectrum antibiotics and chemotherapy, irradiation of the abdominal and pelvic organs, during long-distance travel) or a delay in the development of permanent flora in infants can cause digestive disorders (such such as flatulence, diarrhea and constipation).

Regular intake of LA-5 and BB-12 effectively reduces the frequency and severity of mild to moderate symptoms of digestive disorders (mainly diarrhea) associated with an imbalance of intestinal microflora, and also normalizes the functioning of the gastrointestinal tract.

Linex for children sachets No. 10

Name

Linex for children (1.5g sachets) No. 10

Description

Sachet sachet for preparing a solution for oral administration. Recommended as a dietary supplement - a source of probiotic microorganisms.

Main active ingredient

Bifidobacteria animalis BB 12

Release form

powder for preparing solution

Dosage

1.5g

special instructions

Oral solution. For children from birth.

pharmachologic effect

Recommended as a dietary supplement - a source of probiotic microorganisms. The probiotic Linex for children® contains important bifidobacteria for children: Bifidobacterium animalis subsp. lactis (BB-12). Bifidobacterium BB-12 is found in breast milk and begins to colonize the intestines of a newborn from the first hours of life. This strain is highly safe, well tolerated and clinically effective in children from the neonatal period. Bifidobacteria contribute to the natural formation of normal microflora and intestinal function, and also create an optimal environment in the intestines for the action of digestive enzymes. In addition, bifidobacteria ensure the correct formation of immunity and help reduce the risk of developing infectious diseases, the possibility of atopic dermatitis and food allergies in young children. In breastfed children, bifidobacteria make up 60-91% of the microflora.

Indications for use

Establishing and maintaining a balance in the composition and functional state of the intestinal microflora, including in children of the first year of life with digestive disorders such as colic*, gas formation, stool disorders (constipation, diarrhea) and other digestive disorders; Maintaining the balance of the composition and functional state of the intestinal microflora when taking antibiotics and after completing a course of antibiotic treatment; Reducing the risk of diarrhea caused by viral or bacterial infections of the gastrointestinal tract (including rotavirus infection); Support in the formation and functioning of the immune system. Factors that have a negative impact on the formation of the intestinal microflora of the newborn: Children at risk of imbalance of the intestinal microflora: Caesarean section, premature birth; Unfavorable course of the neonatal period; Late breastfeeding; Long stay in the maternity hospital; Early artificial feeding; Physiological immaturity of intestinal motor function; Unbalanced diet. Unfavorable moments in a child’s life (risk of imbalance of intestinal microflora): Stopping breastfeeding; Introduction of complementary foods; Teething; Hospitalization; Changing of the living place; Separation, even short-term, from the mother when she goes to work; Weaning from the breast, from the pacifier. These factors disrupt the natural colonization of the intestines with beneficial bacteria and can cause an imbalance of microflora (dysbacteriosis), and therefore children at risk for imbalance of microflora are more prone to functional disorders of the gastrointestinal tract (GIT), food allergies, and are more susceptible to GIT infections.

Directions for use and doses

Children from birth to 7 years – 1 sachet 1 time per day with meals; children from 7 to 12 years old: 2 sachets per day with meals. Open the sachet and mix the contents with milk, juice or other baby food. Do not mix the contents of the sachet with hot drinks - the temperature of the product should not exceed 35°C. When prescribed simultaneously with antibiotics, take no earlier than 3 hours after using the antibiotics. The recommended duration of use is 30 days. If necessary, the dose can be repeated after 1 month.

Contraindications

Individual intolerance to dietary supplement components. Before use, you should consult your pediatrician.

Compound

COMPOSITION (per 1 sachet): filler maltodextrin 1400 mg, lyophilized bifidobacteria powder 100.0 mg. The number of probiotic microorganisms Bifidobacterium animalis (strain DSM No. 15954) is not less than 1.0x108 CFU/g (which corresponds to 1.5x108 CFU/sachet). Maltodextrin is a product of incomplete hydrolysis of starch and is non-toxic. It is an inert auxiliary substance, neutral for the baby’s digestion.

Side effect

The drug is well tolerated. There are no reports of undesirable effects, but the possibility of hypersensitivity reactions cannot be excluded.

Storage conditions

In a dry place, at a temperature not exceeding 25 °C. Shelf life: 2 years.

Linex powder sachet 1.5g No. 10

Compound

For 1 sachet:

filler maltodextrin - 1400 mg;
lyophilized bifidobacteria powder - 100 mg.

The number of probiotic microorganisms Bifidobacterium animalis (strain DSM No. 15954) is not less than 1.0x108 CFU/g (which corresponds to 1.5x108 CFU/sachet). Maltodextrin is a product of incomplete hydrolysis of starch and is non-toxic. It is an inert auxiliary substance, neutral for the baby’s digestion.

Indications for use

establishing and maintaining a balance in the composition and functional state of the intestinal microflora, including in children of the first year of life with digestive disorders such as colic, gas formation, stool disorders (constipation, diarrhea) and other digestive disorders;
maintaining a balance in the composition and functional state of the intestinal microflora when taking antibiotics and after completing a course of antibiotic treatment;
reducing the risk of diarrhea caused by viral or bacterial infections of the gastrointestinal tract (including rotavirus infection);
support in the formation and functioning of the immune system.

Contraindications

Individual intolerance to components.
Before use, you should consult your pediatrician.

Directions for use and doses

children from birth to 2 years old, 1 sachet 1 time per day with meals;
children from 2 to 7 years old, 1 sachet per day;
children from 7 to 12 years old, 2 sachets per day with meals.

Open the sachet and mix the contents with milk, juice or other baby food. Do not mix the contents of the sachet with hot drinks - the temperature of the product should not exceed 35°C. The recommended duration of use is 30 days. If necessary, the dose can be repeated after 1 month.

Storage conditions

Store in a place protected from light at a temperature not exceeding 25°C.

Best before date

2 years.

special instructions

Dietary supplement (dietary supplement).
Not a medicine. Linex should not be washed down with hot drinks or taken simultaneously with alcohol.

You should consult your doctor before taking the drug if you:

body temperature above 38°C;
traces of blood or mucus in the stool;
diarrhea lasts more than two days and is accompanied by acute abdominal pain;
dehydration and weight loss, chronic diseases - diabetes, AIDS.

When treating diarrhea, it is necessary to replace lost fluids and electrolytes.

Description

The probiotic Linex for children® contains important bifidobacteria for children: Bifidobacterium animalis subsp.
lactis (BB-12). Bifidobacterium BB-12 is found in breast milk and begins to colonize the intestines of a newborn from the first hours of life. This strain is highly safe, well tolerated and clinically effective in children from the neonatal period.

Bifidobacteria contribute to the natural formation of normal microflora and intestinal function, and also create an optimal environment in the intestines for the action of digestive enzymes. In addition, bifidobacteria ensure the correct formation of immunity and help reduce the risk of developing infectious diseases, the possibility of atopic dermatitis and food allergies in young children. In breastfed children, bifidobacteria make up 60-91% of the microflora.