Pharmacodynamics and pharmacokinetics
The antibacterial activity of the active substance, like all other sulfonamides , is due to the fact that the structure of the drug is similar to para-aminobenzoic acid , which is directly involved in the synthesis of folic acid in the microbial . And the development and growth of harmful microorganisms directly depends on the processes of synthesis of purine and pyrimidine bases, with the help of folic acid . The use of sufficiently large doses of phthalylsulfathiazole makes it possible to eliminate microbes, despite the reserves of PABA in tissues, and prevents the formation of new, more resistant strains of microorganisms .
The drug also has an anti-inflammatory effect. It stimulates the production of glucocorticosteroids and reduces the intensity of leukocyte .
The drug exhibits the greatest activity against Pneumococcus, Meningococcus, Shigella dysenteriae, Streptococcus, Gonococcus, Staphylococcus, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli.
After taking the drug, its greatest concentration is concentrated in the rectum (most of all in the intestinal lumen ).
Children
- If you are upset, you should not take the drug for more than 3 days.
1 day - 0.1 g per kilogram of body weight, the child must be given medicine 4 times a day.
- 2 and subsequent days - 0.05 g per kilogram of the baby’s body weight, the volume of the medicine is divided into 3 doses.
If you have mild digestive upset, you should not take the medicine for more than 3 days.
Pregnant women should not take this remedy. It is prescribed as a last resort and is drunk only under medical supervision.
But for nursing women, Fthalazol is prescribed without fear. This drug does not pass into breast milk, so it cannot cause any harm to the baby. It is prescribed to nursing mothers without restrictions.
According to experts, taking Phthalazole should be supplemented with B vitamins. You can drink nicotinic acid, riboflavin, and thiamine. This technique allows you to limit the proliferation of E. coli, which are involved in the synthesis of the listed vitamins.
It is advisable to take the medicine with warm mineral water without gas. Milk. It is recommended to take Fthalazol one hour before meals.
Indications for use of Phthalazol
What does Phthalazol help with?
- from diarrhea caused by bacteria;
- from shigellosis ;
- from colitis and enterocolitis ;
- treatment of chronic dysentery during exacerbations;
- gastroenteritis.
What else are Fthalazol tablets prescribed for?
Indications for the use of Phthalazole may include conditions after intestinal surgery .
pharmachologic effect
Since Fthalazol belongs to antibacterial agents (a group of sulfonamides), it is used to combat intestinal infections. It has a narrowly targeted effect because it is not absorbed into the blood.
However, like other antibacterial drugs, Fthalazol not only destroys pathogenic microflora, it creates favorable conditions for the proliferation of Candida fungi, because both pathogenic and beneficial bacteria are destroyed.
Therefore, you should not take Fthalazol for a long time; this is a serious drug that can get rid of an intestinal infection, but at the same time lead to candidiasis.
Watch the thematic video about Fthalazol tablets:
Instructions for use of Phthalazole (Method and dosage)
The dosage and duration of treatment should be prescribed by a specialist, depending on the degree of sensitivity microflora to sulfonamides.
According to the instructions for Fthalazol, the daily dose should not exceed 7 grams, and a single dose should not exceed 2 grams.
In acute cases of the disease, the following is prescribed:
- 1-2 days – 2 tablets, every 4 hours;
- 3-4 days – 2 tablets, every 6 hours;
- Day 5-6 – 2 tablets – every 8 hours.
Further treatment:
- 1-2 days - 2 tablets every 4 hours, at night - one (in total - 10);
- 3-4 days – 8 tablets per day, with an interval of 4 hours, except at night;
- Day 5 – 6 tablets, every 4 hours.
How to take Fthalazol for children?
For children, the daily dose is reduced to 0.2 g per kg of weight (children under 3 years old), to 0.4-0.8 g per kg of weight (over 6 years old). The drug intake is divided into equal parts, the sleep schedule is not disturbed. The course of treatment is usually one week.
Description
Fthalazol: tablets
Phthalazol is produced in the form of tablets. They are yellowish in color, flat in shape and are familiar to almost everyone, because for many years they have been considered a mandatory remedy that should be kept at home in case of poisoning and other situations related to disturbances of the intestinal microflora.
Packed in blister packs of 10 pieces. Phthalazole belongs to the sulfonamide group and helps cope with microbial lesions of the intestinal mucosa.
Interaction
Do not combine with acids, hexamethylenetetramine, adrenaline and acid-reacting agents .
When taking Phthalazol simultaneously with oxacillin , the effectiveness of the latter is reduced.
When combined with levomycin, nitrofuran and thioacetazone, the risk of side effects increases.
Barbiturates and para-aminosalicylic acid, antibiotics and other sulfonamides enhance the effect of the drug on harmful microorganisms.
Combination with indirect anticoagulants enhances the activity of the latter.
Contraindications
Side effects are common.
Listed below are the main conditions that are a contraindication for taking Phthalazol.
- Graves' disease.
- Hepatitis.
- Blood diseases.
Also, taking the drug is not recommended for children under 2 years of age. Another absolute contraindication to treatment with this drug is individual intolerance.
If problems with the intestines began due to fungal infections of the intestinal mucosa, then taking Phthalazole will only worsen the situation. In this case, you should not drink this medicine, because this medicine will create good conditions for the development of fungi such as Candida.
The drug is prescribed with caution to patients with nephritis and nephrosis.
Phthalazol price (where to buy)
The price for 10 tablets of the medicine is about 30 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Phthalazol tablets 500 mg 10 pcs JSC Dalkhimfarm
273 rub. order
Pharmacy Dialogue
- Phthalazol (500 mg tablet No. 10) DHF JSC
RUB 252 order
- Phthalazol (500 mg tablet No. 10) Dalkhimfarm
220 rub. order
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Pharmacy24
- Phthalazol 0.5 No. 10 tablets PAT "Lubnipharm", Ukraine
6 UAH. order - Ftalazol-KMP 500 mg N10 tablets PAT "Kievmedpreparat", Ukraine
10 UAH.order
- Ftalazol-Darnitsa 500 mg No. 10 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
9 UAH order
- Phthalazol 0.5 N10 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
10 UAH.order
PaniPharmacy
- Fthalazol tablets Fthalazol tablets. 0.5g No. 10 Ukraine, Health LLC
7 UAH order
- Fthalazol tablets Fthalazol tablets. 0.5g No. 10 Ukraine, Kievmedpreparat OJSC
12 UAH order
- Fthalazol tablets Fthalazol tablets. 0.5g No. 10 Ukraine, Lubnyfarm PJSC
6 UAH order
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What diseases does the drug help against?
Phthalazole has a detrimental effect on:
- staphylococci;
- gonococci;
- dysentery bacillus;
- streptococci;
- Pseudomonas aeruginosa and Escherichia coli;
- pneumococci.
The anti-inflammatory effect of the drug is explained by increased production of glucocorticosteroids in the body and a decrease in leukocytes in the area of the infectious focus. The main part of Phthalazole is concentrated in the lumen of the large intestine; only a tenth of the active component enters the blood.
The pathogenic flora destroyed by phthalylsulfathiazole is eliminated along with the remains of the drug naturally. Once the drug enters the systemic circulation, it exits through the kidneys and liver.
Phthalazole does not accumulate and does not lead to addiction. The antidiarrheal activity of the drug persists even with repeated use.
Possible adverse reactions and overdose
Phthalazole is characterized by low toxicity, but in case of increased individual sensitivity or failure to comply with the standard dosage, it can lead to atypical reactions.
Most often, during treatment with the drug, the following side effects are observed:
- painful cramps in the lower abdomen;
- decreased appetite;
- nausea with vomiting;
- flatulence;
- constipation;
- intestinal candidiasis with long-term therapy;
- allergic reactions in the form of rashes on the body, urticaria, skin hyperemia.
If severe adverse reactions are detected, the use of Phthalazol is stopped, treatment of diarrhea is continued with an analogue with other active ingredients.
An overdose of the drug is indicated by severe pain in the head, vomiting, inflammation of the mucous membranes of the mouth, mood swings, cholangitis, hepatitis, gastritis. In case of acute single overdose, gastric lavage is performed and symptomatic treatment is prescribed. It must include folic acid (B6), since phthalylsulfathiazole destroys this vitamin.
