Venter

Pharmacodynamics and pharmacokinetics

The composition of the drug includes the active substance - sucralfate - a disaccharide, including aluminum hydroxide and sucrose sulfate. When taking the drug, rapid healing of peptic ulcers , prevention of the development of gastric and duodenal , and protection of the gastric mucous membranes from the influence of pepsin and hydrochloric acid .

Treatment with Venter can reduce pepsin by 30%, without having any particular effect on the acidity of gastric juice. In this case, the mechanism of action of the drug is based on the binding of sucralfate to the proteins of the affected tissues of the mucous membranes, causing the formation of a protective film on the surface of the ulcer. The drug accelerates the regeneration of damage, scarring of ulcers, prevents the development of relapses of ulcers and the formation of stress ulcers . The absorption of phosphates in the gastrointestinal tract also decreases.

When taken orally, the substance is slightly absorbed into the systemic circulation. In the body, the drug does not form clinically significant concentrations in plasma and does not exhibit a systemic effect. The substance is not metabolized inside the body. Partial excretion of the drug occurs through the kidneys, the rest - unchanged through the intestines.

Pharmacological properties of the drug Venter

A remedy for the treatment of peptic ulcers. Sucralfate protects the gastric mucosa without having a systemic effect and having virtually no effect on the acidity of gastric juice. Sucralfate binds to the proteins of necrotic tissue in the area of ​​the ulcer, forming a protective coating that prevents the action of pepsin, hydrochloric acid of gastric juice and bile salts. Sucralfate reduces pepsin activity by approximately 30%. Accelerates the scarring of peptic ulcers of the stomach and duodenum, prevents their recurrence and the formation of stress ulcers, and also reduces the absorption of phosphates from the digestive tract. After oral administration, ≤5% of sucralfate is absorbed, as a result of which the drug has no systemic side effects. The absorbed part of the drug is excreted by the kidneys.

Side effects

During treatment with Venter, the following may develop: constipation , nausea , flatulence, vomiting , diarrhea , dry mouth, headache, drowsiness , dizziness, gastralgia , lower back pain, allergic reactions and so on.

Venter granules and tablets, instructions for use (Method and dosage)

According to the instructions for use of Venter, the drug in tablets or granules is taken orally. In this case, the tablets are swallowed whole with the required amount of water. When the whole tablet is difficult to swallow, it can be dissolved in water and then drunk. The granules must be pre-dissolved in water.

The prepared solution should be taken 30-60 minutes before meals. The duration of therapy is determined by a specialist, taking into account the complexity of the disorder and the individual characteristics of each patient.

For adult patients, the daily dosage is 2 tablets or 2 sachets - one taken before lunch, the second before bed.

If the patient is diagnosed with hyperphosphatemia , then the dosage is reduced. The presence of peptic ulcers allows the daily dose to be increased by 2 times. The therapeutic course for patients with peptic ulcers of the stomach and duodenum is about 12 weeks. The disappearance of symptoms is not a signal to discontinue the drug; as a rule, treatment is continued until a diagnostic examination that confirms scarring of the ulcers.

Prevention of stress ulcers is carried out by prescribing for adult patients one tablet or a bag of granules to be taken 6 times a day. To prevent relapse of peptic ulcers, take one tablet or sachet 2 times a day. The maximum permissible daily dosage is 8 tablets or sachets. In case of renal dysfunction, patients have a reduced therapeutic course.

Children over 4 years old are recommended to take 0.5-1 tablet no more than 4 times a day. It is not recommended to take the drug in the form of granules in childhood.

Special instructions for the use of the drug Venter

The small amount of aluminum contained in sucralfate is absorbed in the digestive tract and subsequently excreted in the urine. In case of severe renal dysfunction, aluminum may accumulate in the body with the development of its toxic effect. The risk of accumulation increases with simultaneous administration of other drugs containing aluminum (for example, some antacids). The safety and effectiveness of sucralfate in children under 4 years of age have not been sufficiently studied, so it is not recommended to prescribe the drug to children in this age group. The drug can be used during pregnancy only when the expected benefit to the expectant mother outweighs the potential risk to the fetus. There is no evidence that sucralfate passes into breast milk, so it should be used with caution during breastfeeding.

Overdose

This drug is generally well tolerated by patients, so the risk of overdose is minimized

However, when taking Venter in high doses, intolerance reactions or allergy symptoms may worsen. In this case, the following may develop: nausea, vomiting, abdominal pain, irritation and skin rashes. Such cases require symptomatic therapy.

If patients have renal failure, then with long-term treatment aluminum intoxication encephalopathy or osteomalacia . This requires urgent discontinuation of treatment, hemodialysis, hemofiltration, peritoneal dialysis and deferoxamine.

Interaction

Concomitant use with antacids requires an interval between doses of at least 30 minutes.

Combination therapy can reduce the absorption of tetracyclines , cimetidine, ciprofloxacin, ranitidine, norfloxacin, digoxin , indirect anticoagulants, ofloxacin and theophylline . In this case, it is also necessary to maintain an interval that should be more than 2 hours.

The combination of Venter and Phenytoin reduces the absorption and normal concentration of phenytoin , which can cause resumption of seizures. Therefore, it is important to maintain a 2-hour interval.

Venter drug interactions

Antacids can be prescribed during treatment with sucralfate, but they should be taken at least 30 minutes before taking sucralfate or 1.5 hours after taking it. Medicines containing aluminum compounds (for example, some antacids) may cause aluminum to accumulate in the body in patients with kidney failure. Sucralfate may reduce the absorption of certain drugs, such as tetracycline, cimetidine, ranitidine, fluoroquinolones, digoxin, theophylline, warfarin, ketoconazole, levothyroxine, quinidine and phenytoin. These medications should be taken at least 2 hours before taking sucralfate. Sucralfate may bind to some food proteins. For patients being fed by gastric tube, sucralfate should be administered separately from food and other medications.

Venter's analogues

Level 4 ATC code matches:
Ventrisol

Novobismol

Vis-Nol

De-Nol

Gastrocepin

Dalargin

Vikair

Omez DSR

Omez D

Gastrofarm

Gaviscon

Vikalin

The main analogues of Venter are represented by the following drugs: Alsukral, Ankrusal, Sucralfate, Sukrat and Ulgastran.

Also, a similar effect is typical for: De-Nol, Maalox, Almagel and Rennie.

Reviews about Venter

Various forms of disorders of the digestive system and gastrointestinal tract bother many people. At the same time, for some, these may be minor deviations caused by overeating or other malnutrition, while for others, more complex and aggravated forms in the form of ulcers and gastritis . In any case, there are a lot of reviews about Venter and drugs that have a similar effect on the Internet.

Users report that this medicine affects different people differently and does not always help get rid of problems in the gastrointestinal tract. At the same time, they say that they started taking Venter after recommendations from friends, random people on the Internet, or pharmacy employees. It should be noted that in addition to this drug, they also took Omez, Phosphalugel, Rennie, and so on at different times.

Thus, it may take a long time to independently select a drug until the stomach pain increases significantly. Only after this do patients turn to a specialist who diagnoses them with a serious disorder. However, most people do not blame themselves for this, but the pills, which turned out to be useless and did not help them recover. Therefore, there is no need to prolong the pain until it worsens, but you should immediately consult a doctor.

Venter

Release form: tablets (blister packs) 500 mg

Pharmacological group - gastroprotective agent

pharmachologic effect

• antiulcer
• increasing prostaglandin synthesis
• reducing pepsin activity
• forming a protective film

Ingredients – sucralfate 500 mg

Indications

• Gastritis and duodenitis
• Gastritis, unspecified
• Gastroesophageal reflux
• Gastroesophageal reflux with esophagitis
• Gastrojejunal ulcer
• Gastroduodenitis, unspecified
• Alcoholic gastritis
• Acute hemorrhagic gastritis
• Peptic ulcer of unspecified localization
• Chronic gastritis, unspecified
• Chronic atrophic gastritis
• Chronic superficial gastritis
• Esophagitis
• Other gastritis
• Other diseases of the esophagus
• Other acute gastritis
• Esophageal ulcer
• Duodenal ulcer
• Stomach ulcer

Composition by components

• sucralfate

Pharmacodynamics

It has gastroprotective, antiulcer effects, forming a protective film, increasing the synthesis of prostaglandins, reducing the activity of pepsin. It has a local effect on ulcerative lesions of the mucous membrane of the stomach and duodenum. Dissolves in an acidic environment, most of the drug forms an adhesive polymer paste with basic properties. Being in the stomach and duodenum, it is transformed into a polyanion with many free negative charges, which form strong bonds with positive radicals of mucosal proteins. Thus, it forms a strong barrier that, over a long period, protects the affected areas of the mucous membrane from the influence of aggressive factors (acid, bile and pepsin do not come into contact with the ulcerated surface). It has a cytoprotective effect, promoting the synthesis of prostaglandins in the mucous membrane. The drug moderately inhibits the activity of pepsin.

Pharmacokinetics

It is poorly absorbed from the gastrointestinal tract and therefore does not have a significant systemic effect. The drug is absorbed by 3-5% of the administered dose, more than 90% is excreted unchanged in the feces.

Application

Peptic ulcer of the stomach and duodenum in the acute phase; reflux esophagitis gastritis, gastroduodenitis, heartburn, drug ulcer.

Dosage regimen

Prescribe 1 g 4 times a day (1 hour before meals and before bedtime). It is also possible to take it twice a day: 2 tablets or 2 bags of granules in the morning and evening. The maximum daily dose is 8 g. The tablet can be swallowed whole with a small amount of liquid, or, like granules, mixed in 0.5 glasses of water and drunk. The average duration of treatment for peptic ulcer is 4-6 weeks. If necessary, treatment is continued for up to 12 weeks.

Side effects

When used according to indications and in the recommended dosage, patients usually tolerate the drug well. In rare cases - dyspeptic disorders (constipation, diarrhea, nausea, dry mouth), itching, pain in the lumbar region, insomnia, dizziness. In patients with renal failure, serum aluminum and phosphate concentrations should be monitored.

Contraindications

Pregnancy, children (up to 4 years), severe renal dysfunction, bleeding from the gastrointestinal tract (GIT), hypersensitivity.

Interaction

If it is necessary to prescribe antacids simultaneously, they should be taken 30 minutes before or 30 minutes after taking sucralfate. In case of insufficiency of renal function, monitoring of the concentration of aluminum and phosphates in the blood serum is necessary. Sucralfate reduces the absorption of tetracyclines, cimetidine, ciprofloxacin, norfloxacin, ranitidine, digoxin, warfarin and theophylline. Therefore, the interval between taking sucralfate and the above drugs should be at least 2 hours.

special instructions

There are no known harmful effects of the drug on the fetus or child. However, for pregnant women and breastfeeding women, treatment is recommended only in urgent cases.

Venter price, where to buy

The price of Venter in tablets in Russian pharmacies varies between 200-250 rubles.

It is quite difficult to buy the drug in granules in Russian pharmacies. In Ukraine, its cost is 133 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

• Venter granules 1g No. 50
  RUB 4,880 order
• Antepsin (analogue of Venter) 1 g tablet No. 60

  2700 rub. order

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Pharmacy24

• Venter 1 g No. 50 tablets KRKA, Slovenia
  206 UAH. order