Nizatidine is an antiulcer drug

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Nizatidine is a representative of antiulcer drugs for the gastrointestinal tract. According to the pharmacotherapeutic classification, it belongs to drugs that block histamine receptors.

• 1 Components and form of the drug
• 2 Medicinal effects on the body
• 3 Indications for use
• 4 Method of application
• 5 Adverse reactions
• 6 Drug interactions
• 7 Analogues and price
• 8 Patient reviews

Instructions for use

Before starting treatment, you must read the instructions for use. This will avoid errors during the treatment process and complications.

pharmachologic effect

Nizatidine has antiulcer pharmacological effects. Helps block histamine H2 receptors, inhibit basal and stimulated (caffeine, food, betazol, histamine, pentagastrin, acetylcholine) production of hydrochloric acid by parietal cells.

When taken orally, it is absorbed quite completely and quickly. Bioavailability is approximately 70%. Cmax is reached 0.5-3 hours after administration. Partially (35%) circulates in the vascular bed in a protein-bound form. Can penetrate organs and tissues: kidneys, pancreas, liver, gastrointestinal tract, etc. The half-life is 1-2 hours. It is predominantly excreted unchanged during urination (60%), and to a lesser extent in feces (less than 6%). The extent of renal excretion depends on tubular secretion and glomerular filtration.

Indications for use

It is very important to notice signs of a stomach ulcer in time and consult a doctor to prevent the development of serious complications. You cannot do without this medication for the following diseases:

• Benign gastric ulcer;
• Duodenal ulcer;
• Inflammation of the esophagus;
• Acute pancreatitis;
• Chronic pancreatitis.

Mode of application

The daily dose of the drug should not exceed 480 mg. If the disease is associated with the stomach, you need to take the medicine twice a day, 150 mg.

To prevent exacerbation of duodenal ulcers, you need to take the medication once a day, 150 mg. When treating the stomach and esophagus, the drug is used in the same amount twice a day.

In the process of treating heartburn and acid indigestion, take this medicine once a day thirty minutes before meals. The dose amount is 75 mg.

Adults and adolescents are allowed to take the drug. It is prohibited for children.

Release form, composition

The drug is produced in the form of capsules. The component of the medicine is ranitidine hydrochloride.

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Interaction with other medications

When taking Nizatidine with other medications, you must follow the regimen. There should be a two hour interval between medication doses. Then each of the medications will be effective and there will be no complications.

Medicinal effects on the body

Due to its ability to block histamine receptors, the drug suppresses the release of hydrochloric acid. It affects both its own pathological production of excess acid and secretion stimulated by various substances. This could be acetylcholine, histamine, gastrin, caffeine.

By reducing the secretion of hydrochloric acid, it reduces the acidity of gastric juice and the activity of enzymes that break down peptide compounds in the digestive tract. Thanks to this, antiulcer and analgesic effects are achieved, the functioning of the digestive tract is improved and the load on the pancreas is reduced.

Absorbed quickly when administered orally, binds to blood proteins. Penetrates into the tissues of the pancreas, liver, kidneys and gastrointestinal tract. The half-life is up to two hours. Most of it is excreted in urine, and up to six percent is excreted in feces.

Side effects

In certain cases, it is necessary to refrain from using the drug.

Before using the drug, you must carefully study the instructions, which contain information about its side effects.

Overdose

The use of large doses of Nizatidine is fraught with the appearance of increased salivation, diarrhea, lacrimation, vomiting, and miosis. Treatment options include the use of activated charcoal, symptomatic treatment, induction of vomiting, or lavage.

Contraindications

You should not take Nizatidine if you have the following symptoms:

• Hypersensitivity to the drug;
• Allergy;
• Children under 14 years of age;
• Renal dysfunction;
• Pregnancy;
• Lactation.

During pregnancy

The drug may cause side effects, so it should not be taken during pregnancy. It is necessary to find an analogue that will not have a negative impact.

Adverse reactions

Nizatidine can provoke gastrointestinal disorders, changes in blood count and allergic reactions. Disorders of the digestive tract when taking Nizatidine are characterized by nausea, and less often - spasms. Possible damage to liver tissue.

Allergic reactions manifest themselves in the form of urticaria, excessive sweating, anaphylactic shock, bronchial spasm, swelling of the larynx and facial tissues.

Laboratory testing may result in a decrease in the level of hemoglobin and platelets in the blood and an increase in the concentration of eosinophils. Undesirable reactions such as gynecomastia, changes in heart rate, and increased concentrations of uric acid in the urine are less common.

If you detect any unwanted reactions, you should consult your doctor. He will adjust the drug intake or cancel it and prescribe an analogue in action.

Overdose

Symptoms of overdose include lacrimation and increased salivation. The patient complains of nausea, develops diarrhea and vomiting. To eliminate an overdose, take activated charcoal, prescribe symptomatic medications, and induce vomiting.

special instructions

1. Before starting therapy, it is important to make sure that there are no malignant pathologies of the duodenum, stomach, or esophagus.
2. Nizatidine should be taken no earlier than 2 hours after taking ketoconazole and itraconazole. This avoids a decrease in the absorption of these drugs.
3. Nizatidine helps suppress the skin response to histamine, causing false negative results. To avoid this development, you should stop taking the medication before performing skin tests to detect an immediate allergic skin reaction.
4. Nizatidine may counteract the effect of histamine and pentagastrin on one of the most important functions of the stomach (acid production), so the medicine should not be used during the day before the test.
5. During therapy, it is recommended to avoid drinks, foods and drugs that can irritate the gastric mucosa.
6. During therapy, false-positive test reactions to urobilinogen in the urine are possible.

Impact on the ability to drive vehicles and operate machinery

The medicine does not affect the ability to concentrate.

Pregnancy and lactation

The drug should not be used during pregnancy. Treatment with the drug may be accompanied by the development of side effects, so its use during pregnancy is prohibited. The doctor must select for the patient a similar remedy that does not have a negative impact on the health of the child and mother.

Use in pediatrics

Nizatidine is not prescribed for children.

Use in old age

For elderly people, Nizatidine is prescribed with caution, since the risk of impaired renal function with such therapy increases. Therefore, the physician should take this into account when choosing the dosage.

For impaired renal function

When treating people with renal failure, the dose is reduced depending on the CC indicators.

For liver dysfunction

Treatment of people with impaired liver function does not require adjustment of the dosage regimen.

Conditions for dispensing from pharmacies

Nizatidine is a prescription medication.

Indications for use

Nizatidine is indicated for use in patients with the following pathologies:

• ulcerative-erosive lesions of the duodenum during an exacerbation;
• benign ulcerative lesions of the gastric mucosa in the acute phase;
• reflux esophagitis;
• complications of ulcers and erosions of the digestive tract;
• acute bleeding of the gastrointestinal tract;
• inflammation of the pancreas.

Prescribed to patients with exacerbation of chronic pancreatitis. As a prophylactic agent it is prescribed to prevent exacerbations of ulcerative and erosive lesions of the stomach and intestines.

Before prescribing the drug to patients with ulcers and erosions, the condition of the digestive tract should be diagnosed. Use for malignant ulcerative lesions is contraindicated. This is due to the fact that nizatidine is able to mask the manifestations of malignant lesions, thereby slowing down the correct diagnosis and prompt treatment.

Contraindications

The drug has a fairly high safety profile, and therefore has a minimal set of contraindications. Among them are only episodes of hypersensitivity to the drug in the patient's medical history.

It is forbidden to take Nizatidine during pregnancy and breastfeeding, since the safety and effectiveness of the drug during these periods have not been determined. Treatment is possible only under the supervision of a doctor and with his direct recommendations based on diagnosis.

In pediatrics, the drug is not used due to the lack of studies on the safety and effectiveness of Nizatidine for children.

Analogs

If you cannot find Nizatidine in a pharmacy, you need to purchase its analogues, which are no less effective.

Reviews

Nizatidine is an effective remedy, its effect has been proven by experts. With this drug you can restore the functioning of the stomach and intestines. Pathogenic microorganisms are destroyed, the development of the disease stops. If the patient experienced severe abdominal pain, it will be eliminated.

The microflora of the digestive organs is also restored, since the stomach and intestines are saturated with useful substances contained in the drug.

The medicine has no specific taste or smell. Can be used to combat various stomach ailments, even with inflammation. For diseases of the esophagus, medicine is also often prescribed by specialists.

Adults and teenagers can safely take this drug; children and pregnant women cannot take it; they will have to look for an analogue. Nizatidine causes virtually no side effects.