"Mikrazim": what it helps with, instructions for use, where to buy at an affordable price

If the functions are impaired, the pancreas ceases to produce digestive enzymes (including lipase, trypsin, amylase) in sufficient quantities. Because of this, food digestion processes are disrupted. To restore balance, it is recommended to take medications containing a set of necessary substances. One of the most effective is Mikrazim. It can be used by both adults and children, including those under 1.5 years old.

"Mikrazim": composition and description

"Micrazim" is a drug administered in the form of gelatin capsules containing powder with granules. The active ingredient is pancreatin, the auxiliary components are gelatin, titanium dioxide, dye and water. The content of pancreatin, depending on the type of drug, is 0-128 mg or 320 mg in 1 capsule.

Sold in cardboard packages of 20 or 50 pcs. in everyone. Available in glass containers or polymer packaging. Should be stored under normal room conditions in a dark place at temperatures up to 25 degrees. Access for children is prohibited. The shelf life is 2 years from the date of production.

Description of the drug

Creon is a drug manufactured by Abbott Laboratories. The average price is 330-500 rubles. The main active ingredient is pancreatin. It corresponds to the content of the following components:

• lipase (10,000 units);
• amylase (8,000 units);
• protease (600 units).

These are the main enzymatic substances involved in food processing and the formation of feces. Under the influence of active components the following pharmacological effects are formed:

• digestion of carbohydrates, fats, proteins;
• rapid absorption of nutrients through the small intestine;
• compensation for insufficient enzyme production in inflammatory diseases of the pancreas.

Under the influence of the medicine, the digestion process is facilitated. Nutrients do not penetrate into the systemic circulation; they are eliminated along with feces. The product helps with the following conditions:

• insufficient production of enzymes in diseases of the pancreas, cystic fibrosis;
• inflammation of parts of the digestive tract that impede the absorption of food and the formation of feces;
• removal of part of the stomach, chemotherapy;
• improper diet containing a lot of fat (body weight increases, the patient is prone to obesity).

The remedy not only heals. It is used to prepare for x-ray examination of the gastrointestinal tract and abdominal organs. Pancreatin helps to evacuate the contents of the digestive tract.

Side effects contraindications

If the dosage is followed, the drug is well tolerated by all patients. Negative reactions arise due to an error in the concentration of the drug or the course of use prescribed by the doctor. But individual intolerance may occur, then the following side effects are formed:

• dyspeptic disorders, nausea, vomiting, impaired stool formation;
• lack of effectiveness when drinking alcohol in large quantities (this is prohibited);
• allergic reactions on the skin (rash, itching, peeling, swelling, redness);
• an increase in the level of uric acid in the blood with the further development of gout, if the patient uses the drug in excessively high doses for a long time;
• In infants and children, irritation develops around the anus when consuming high doses.

The drug should not be used only due to acute pancreatitis or hypersensitivity to one of the components. This means that it can be used by children, women during pregnancy and lactation. But they do this only after consulting a doctor and undergoing laboratory and instrumental tests. This will prevent complications that negatively affect the fetus.

Indications for use of the drug "Micrazim"

Capsules are taken in case of digestive upset, as well as in preparation for certain types of research:

• replacement course of treatment for pancreatic pathology (including chronic pancreatitis, dyspepsia, diarrhea not associated with infectious causes, cystic fibrosis);
• insufficient production of digestive enzymes (including due to poor nutrition, insufficiently active lifestyle, due to prolonged immobilization, bed rest);
• changes in the activity of the heart when exposed to receptors of the stomach and esophagus;
• insufficient digestion;
• bile stagnation;
• violation of chewing function;
• steatorrhea;
• problems with the absorption of nutrients in the postoperative period;
• preparation for ultrasound or x-ray.

How they affect the body

The main substance of the drugs is pancreatin, which is a combination of protease, lipase and amylase. Despite this, they act differently. Micrazim is a medicine related to digestive enzyme agents. Pancreatin belongs to the groups of enzymes and antienzymes.

The difference between them is the dosage of the main component.

Pharmacological characteristics

These two drugs have identical pharmacological effects. Remedies help normalize digestive processes:

1. Pharmacodynamics: the composition begins to act approximately 30-40 minutes after administration.
2. Pharmacokinetics: medications are not afraid of stomach acid, they are activated in the intestines, where they begin to act.

Contraindications and side effects

The drug does not have many contraindications. But in some cases the reception is excluded:

• acute pancreatitis;
• chronic pancreatitis at the acute stage;
• individual intolerance to the active and/or additional components.

There is no data on the use of the drug during pregnancy and breastfeeding, since relevant studies have not been conducted. Therefore, pregnant and breastfeeding women will need to obtain additional medical advice. The drug is prescribed only if the expected benefits clearly outweigh the possible risks.

Side effects are rare, but allergic reactions cannot be ruled out. If taken in high doses, nausea or diarrhea, constipation, pain, bloating and other foreign sensations in the abdomen may occur. Less commonly, hyperuricemia or hyperuricosuria may develop during long-term therapy.

Comparison of the safety of Micrazym and Pancreatin

The safety of a drug includes many factors.

At the same time, in Mikrasim it is quite similar to Pancreatin. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Mikrasim, as well as Pancreatin, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Micrasim does not have any risks when used, just like Pancreatin.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Micrasim and Pancreatin.

Instructions for use "Micrazim"

The dosage is determined in units of pancreatin content:

• 1 tablet of 128 mg corresponds to 10,000 units;
• 1 tablet of 320 mg corresponds to 25,000 units.

The drug is taken by both adults and children at any age, including newborns (in consultation with the doctor). The capsule is taken orally, and if it is impossible to swallow whole, open it and take the powder orally with water or other liquid.

The recommended daily dosage depends on age:

• children under 1.5 years old 50,000 units;
• children from 1.5 years and adults 100,000 units.

Capsules take up to 1 piece. up to 4 times a day, with a sufficient amount of water. If you take 2 or more capsules, then take the first half of the daily dosage before meals, and the second half with food.

If the daily norm is violated, the concentration of uric acid or blood in the urine increases. Children may experience constipation. In this case, the course is immediately suspended and symptomatic treatment is carried out.

Quantitative differences

In our pharmacies, domestic Pancreatin is presented in a wide range from several manufacturers:

1. Panctreatin LekT (60 tablets)
2. Pharmstandard (60 tablets)
3. Irbitsky chemical plant 25 units (50 tablets)
4. Biosynthesis 25 units (60 tablets)

Let us compare their compositions in more detail with Mikrasim 10000 in terms of modern units.

comparison table

The table shows that Mikrazim, even at a 10-thousandth dosage, is significantly superior to its opponents in enzyme activity. The most profitable competitors are Pancreatin-LekT (Tyumen Federal Plant) and Pharmstandard, although they are almost three times behind in lipase.

60 tab.

Analogues from Biosintez and Irbitsky have very low lipolytic activity per tablet; it makes sense to use them only 3-4 pieces at once in case of mild digestive disorders or a complete absence of fats in the diet.

The entire list of available enzyme preparations (40 pcs) and their activity can be compared here.

Special instructions and drug interactions

Before long-term treatment with pancreatin-based drugs (Mikrazim and analogues), a mandatory consultation with a doctor is indicated, especially if taken in high doses. There is no data on addiction to the active ingredients of the drug, as well as on its effect on concentration, the ability to drive a car, or use complex mechanisms.

The drug can be used simultaneously with almost all medications. But if iron is present in the composition (for example, to increase hemoglobin levels), then while taking Microzim it may be absorbed worse, which will weaken the therapeutic effect.

Comparison of the effectiveness of Micrazym and Pancreatin

Micrazim is more effective than Pancreatin - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Mikrasim is more pronounced, then it is impossible to achieve this effect with Pancreatin even in large doses.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Micrazim and Pancreatin are also different, as is bioavailability - the amount of a drug substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Analogues of the drug "Mikrazim"

There are quite a few analogues of Mikrazim. Among them are the following drugs:

1. Gastenorm" - tablets made in India, which are prescribed in the presence of chronic pancreatitis, problems with the chewing reflex, and insufficiency of pancreatic function. Compared to Micrazim, Gastenorm is more likely to cause allergic reactions.
2. “Mezim Forte 10000” is a well-known drug made in Germany, similar in composition. It is used for heaviness in the abdomen, including due to overeating, as well as for the treatment of digestive disorders, including during operations.
3. “Biofestal” is a direct analogue of “Mezim”, it compensates for the lack of digestive enzymes. Compared to Mikrazim, the product is not recommended for use by young children of preschool age.
4. “Festal” is an analogue of “Biofestal”, used for the same purposes and in similar dosages.
5. "Livonorm" is a biological additive of plant origin. Contains milk thistle extract, a complex of vitamins and other beneficial substances that improve the functioning of the gallbladder.

Comparison of ease of use of Micrazym and Pancreatin

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Mikrasim is approximately the same as Pancreatin. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:44:11

Where to buy Mikrazim: price, reviews

You can buy the product at any pharmacy. The drug is sold freely, without a prescription. The price for a package of 20 capsules is 400-500 rubles, 50 capsules – 750-800 rubles.

Reviews about the drug are almost all positive - more than 90% of buyers recommend it. Among the positive aspects, a quick, noticeable effect, improved digestion, and the absence of side effects and contraindications are noted. Among the disadvantages is the relatively high price. It is also noted that over time, addiction occurs and the therapeutic effect weakens.

Patient reviews

Igor, 45 years old, Murom: “When more digestive problems began, caused by pancreatitis, I consulted a doctor. He prescribed Micrasim, a modern enzyme preparation. These are transparent capsules with a brown cap and light brown balls inside. Swallow easily. There were no side effects listed in the instructions for use. I felt the positive effect immediately, and after completing the prescribed course, my pancreas received a kind of new life.”

Polina, 36 years old, Syzran: “When I was hospitalized with an intestinal infection, I took Pancreatin as part of complex therapy to improve digestion. Time passed, and I again encountered a gastrointestinal problem. I started taking Pancreatin tablets on my own, but did not feel the desired result. Only after 10 days did the bloating and heaviness in the stomach disappear, and the belching went away. I am of the opinion that this drug is intended for healthy people who “sin” to eat a lot and tasty, to improve digestion.”