Spasmalgon is a combination medicine. It contains several active components. This guarantees high efficiency in relieving pain of moderate intensity. In addition, the drug has weak antipyretic and anti-inflammatory properties. When taken, it is possible to eliminate the discomfort associated with pain in a short time. Spasmalgon is often prescribed in the postoperative period, as well as after diagnosis.
Composition of drugs, its effects and release form
The effectiveness of the drug is ensured by the combined composition. The main effects of taking the drug spasmalgon, the instructions for use indicate this, are a pronounced analgesic and antispasmodic effect. Additionally, the medicine lowers body temperature. You need to know what spasmalgon helps with in order to use it correctly.
The peculiarity of the effects of using the product is associated with the following properties of the main components:
- Metamizole sodium effectively relieves pain, lowers body temperature and reduces inflammation.
- Pitophenone hydrochloride has a direct myotropic effect, providing an antispasmodic and vasodilating effect, which helps relieve discomfort.
- Enhances the relaxing effect of the drug fenpiverinium bromide, which belongs to the group of M-anticholinergics.
A special feature of spasmalgon is the high speed of obtaining results. When taking tablets or performing an injection, it is possible to relieve pain in no more than 40 minutes. The number of main components differs in different forms.
You can purchase spasmalgon, which has a combined composition, in a cardboard box in two forms:
- Tablets in blisters.
- Ampoules for injection.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Spazmalgon is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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What does the medicine help with?
Spasmalgon, the instructions for use confirm this, has a wide range of uses. The drug effectively relieves moderate pain of various etiologies.
The medicine has proven its effectiveness against toothache. Its important feature is associated with the properties of smooth muscle relaxation, which eliminates the irradiation of pain in the ear and cheek area, which is practically impossible to endure stoically.
Medicine is prescribed to reduce joint pain in the development of various pathologies. In addition, it is used in the complex treatment of neuralgia and myalgia. After surgical operations, spasmalgon is prescribed as an adjuvant. It is permissible to prescribe medications to reduce fever when treating colds.
With the help of spasmalgon, you can relieve headaches if they are not associated with increased arterial or intracranial pressure, and are also not provoked by cerebrovascular accident. The effectiveness of the drug for migraine, which is characterized by an additional symptom – stomach spasm, has been proven. Thanks to its pronounced antispasmodic properties, spasmalgon successfully copes with this problem.
In addition, the drug effectively copes with headaches caused by sudden changes in weather. This means that it is indispensable for weather-sensitive people.
Spasmalgon copes with pain in organs located in the abdominal cavity. It is recommended to use the medicine for women who suffer from menstrual pain. The drug is considered highly effective for eliminating intestinal, renal, hepatic or biliary colic.
Often among the reviews regarding what spazlmalgon helps with, there are recommendations for using the product for headaches caused by a hangover. But to get a positive result, you need to completely cleanse your body of alcohol. This can be done, for example, with the help of diuretics.
Contraindications and side effects
A direct contraindication to taking spasmalgon is hypersensitivity to all components of the drug. The product should not be used during pregnancy and lactation, as well as for children under 6 years of age. Other contraindications are indicated in the instructions for use of the medicine
Side effects with a single dose are rare. This may include nausea, dizziness and increased blood pressure. With prolonged use of the drug, the risks of disruptions in the urinary and hematopoietic systems increase. An overdose of the drug can provoke dangerous allergic reactions. If this happens, it is necessary to rinse the stomach, induce vomiting, and take absorbents.
Spasmalgon tablets
Instructions for medical use of the drug
Description of pharmacological action
Spasmalgon is a combined analgesic with pronounced antispasmodic activity. The drug Spazmalgon contains three active components - metamizole sodium, pitofenone hydrochloride and fenpiverinium bromide. The mechanism of action of the drug and its pharmacological effects are based on the pharmacological properties of the active components included in its composition. Metamizole sodium is a non-steroidal anti-inflammatory drug, a pyrazolone derivative. Metamizole sodium has a pronounced analgesic effect, has an anti-inflammatory and antipyretic effect. The mechanism of action of metamizole sodium is associated with its ability to inhibit the activity of the enzyme cyclooxygenase, as a result of which the metabolism of arachidonic acid is disrupted and the synthesis of proinflammatory prostaglandins, prostacyclins and thromboxane is reduced. Metamizole sodium belongs to the group of non-selective non-steroidal anti-inflammatory drugs and equally inhibits the activity of both isoforms of the cyclooxygenase enzyme - cyclooxygenase-1 and cyclooxygenase-2. Due to a decrease in the amount of prostaglandins in the inflammation site, there is a decrease in the sensitivity of the chemoreceptors of the endings of afferent neurons of pain sensitivity to bradykinin and histamine. In addition, a decrease in the amount of prostaglandins at the site of inflammation leads to a decrease in the production of endogenous biologically active substances involved in the inflammatory response. Thus, metamizole sodium has an analgesic effect by reducing the activity of the inflammatory process and reducing the effect of inflammatory mediators on pain endings. The antipyretic effect of the drug is associated with a decrease in the amount of prostaglandins in the thermoregulation center in the hypothalamus. Pitophenone hydrochloride is a piperidine derivative that has antispasmodic myotropic activity. The drug has a papaverine-like effect, causing a decrease in tone and relaxation of smooth muscles. Pitophenone hydrochloride helps eliminate pain caused by spasm of the smooth muscles of internal organs. Phenpiverinium bromide is a drug from the M-anticholinergic group, containing quaternary nitrogen in its structure. The drug relieves spasm of the smooth muscle layer of internal organs, reduces tone and reduces motility of the stomach and intestines, relaxes the smooth muscles of the urinary and biliary tract. The pharmacologically active substances that make up the drug Spazmalgon mutually enhance the therapeutic effect of each other. The pharmacokinetic properties of the drug are presented on the basis of the pharmacokinetic parameters of metamizole sodium, since at the moment there are no reliable data on the pharmacokinetics of pitofenone hydrochloride and fenpiverinium bromide. When administered orally, metamizole sodium is well absorbed from the gastrointestinal tract. In the intestinal walls, the drug is hydrolyzed to form a pharmacologically active substance; the peak concentration of the active substance in the blood plasma is observed 30-120 minutes after oral administration. When administered parenterally, the bioavailability of the drug is about 85%. The active substance is partially bound to plasma proteins. Metabolized in the liver to form pharmacologically active metabolites. It is excreted mainly by the kidneys in the form of metabolites, a small part is excreted by the liver. About 3% of the drug is excreted from the body in the form of unchanged metamizole. The amount of the drug that undergoes biotransformation is individual for each patient and depends on many factors, including the genetically determined type of acetylation. In patients suffering from liver cirrhosis, changes in the clearance of metamizole are observed.
Indications for use
The drug Spazmalgon in the form of tablets is used for the symptomatic treatment of patients suffering from pain of mild or moderate intensity, including the drug is indicated for the following diseases: Diseases of the urinary tract, which are accompanied by pain and urinary disorders, including inflammatory diseases of the urinary system and urolithiasis disease. Stomach and intestinal colic, diseases of the digestive tract, which are accompanied by spasm of the smooth muscles of the intestines and stomach and pain. Biliary dyskinesia, cholelithiasis. The drug Spazmalgon in the form of tablets is also used to relieve pain of mild or moderate intensity in primary and secondary dysmenorrhea. If necessary, the drug can be used for the symptomatic treatment of pain in patients suffering from diseases of the musculoskeletal system and neuralgia. However, in this case, the drug is recommended for short-term use. The drug Spazmalgon in the form of an injection solution is used to relieve severe pain caused by spasms of smooth muscles, including: Spasm of smooth muscles of the ureter and bladder, as well as renal colic, which are accompanied by pain of mild to moderate intensity. Diseases of the liver and biliary tract, which are accompanied by severe pain, including hepatic (biliary) colic, biliary dyskinesia, dysfunction of the sphincter of Oddi (postcholecystectomy syndrome). Diseases of the gastrointestinal tract, which are accompanied by spastic pain, including intestinal colic and chronic colitis. Diseases of the pelvic organs, which are accompanied by pain of mild to moderate intensity. Relief of pain in primary and secondary dysmenorrhea.
Release form
tablets 500 mg + 5 mg + 0.1 mg; contour packaging 10, cardboard pack 2. tablets 500 mg + 5 mg + 0.1 mg; contour packaging 10, cardboard pack 5.
Use during pregnancy
At the moment there is no reliable data on the safety of using the drug during pregnancy. If it is necessary to use the drug during lactation, it is recommended to temporarily stop breastfeeding. Restoring breastfeeding is possible no earlier than 48 hours after taking the last dose of the drug.
Contraindications for use
- increased individual sensitivity to the components of the drug and other drugs from the group of non-steroidal anti-inflammatory drugs; - increased individual sensitivity to pyrazolone derivatives; — suspicion of surgical pathology; — dysfunction of the hematopoietic system, including agranulocytosis, leukopenia, aplastic anemia; — the drug is contraindicated in patients suffering from severe liver and/or kidney failure, acute hepatic porphyria, as well as decreased tone of the urinary and/or gall bladder; - the drug is not prescribed to patients suffering from angle-closure glaucoma, tachyarrhythmia and glucose-6-phosphate dehydrogenase deficiency; — spasmalgon is contraindicated in case of obstruction of the gastrointestinal tract, megacolon, collaptoid conditions. In addition, the drug is not prescribed to patients suffering from prostate adenoma, which is accompanied by urinary disorders. It is not recommended to prescribe the drug to women during pregnancy and lactation, as well as to children under the age of 15 years. The drug is prescribed with caution to patients with hay fever, bronchial asthma and allergic rhinitis, as they have an increased risk of developing hypersensitivity reactions. The drug is prescribed with caution to patients suffering from liver and/or kidney diseases, obstructive diseases of the gastrointestinal tract, gastroesophageal reflux disease, decreased intestinal tone, glaucoma, paralytic ileus and diseases of the cardiovascular system. The drug should be prescribed with caution to patients whose work involves operating potentially dangerous machinery and driving a car.
Side effects
When using the drug Spazmalgon, patients experienced the development of the following side effects: From the gastrointestinal tract: nausea, vomiting, dry mouth, pain in the epigastric region, exacerbation of chronic diseases of the gastrointestinal tract, including peptic ulcers and gastritis. From the cardiovascular system and hematopoietic system: increased blood pressure, arrhythmia, increased heart rate, leukopenia, agranulocytosis, thrombocytopenia, anemia, granulocytopenia. From the central nervous system: headache, dizziness, increased irritability, visual disturbances. From the urinary system: difficulty urinating, oliguria, polyuria, anuria, proteinuria, bright red coloration of urine. In isolated cases, mainly in patients taking the drug for a long time, the development of renal dysfunction and interstitial nephritis is noted. Allergic reactions: skin rash, itching, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome. In isolated cases, the development of anaphylactoid reactions, including Quincke's edema and anaphylactic shock, was noted. In patients prone to bronchospasm and patients suffering from bronchial asthma, bronchospasm may develop during therapy with Spazmalgon. If side effects develop when using the drug Smazmalgon, it is recommended to consult your doctor, since some side effects require discontinuation of the drug (including side effects such as impaired renal function, hematopoietic disorders and hypersensitivity reactions).
Directions for use and doses
Orally, after meals, with water, adults and children over 15 years old - 1-2 tablets. 2–3 times a day. Daily dose - no more than 6 tablets. Duration of treatment - no more than 5 days. Increasing the daily dose or duration of treatment is possible only under the supervision of a physician. Children (only as prescribed by a doctor): 6-8 years old - 1/2 tablet, 9-12 years old - 3/4 tablet, 13-15 years old - 1 tablet. 2–3 times a day.
Overdose
When using excessive doses of the drug, patients experience the development of symptoms of metamizole intoxication in combination with anticholinergic effects. Most often, patients develop toxic-allergic syndrome. With a further increase in dose, patients experience the development of disorders of the gastrointestinal tract and central nervous system. There is no specific antidote. In case of an overdose of the drug in tablet form, gastric lavage and the use of enterosorbents are indicated. In case of an overdose of the drug, regardless of the form of release, measures are indicated to quickly remove the drug from the body, including forced diuresis, administration of water-salt solutions and hemodialysis. If necessary, carry out symptomatic therapy.
Interactions with other drugs
Metamizole, which is part of the drug Spazmalgon, is an enzyme inducer, therefore the simultaneous use of the drug Spazmalgon with other drugs should be under the strict supervision of the attending physician. The drug is incompatible with ethyl alcohol, therefore it is necessary to refrain from drinking alcohol and taking medications containing ethyl alcohol during therapy with Spazmalgon. When used simultaneously, the drug reduces the effectiveness of coumarin anticoagulants. When using the drug simultaneously with phenothiazine derivatives, including chlorpromazine, there is a risk of developing severe hypothermia. Spazmalgon, when used simultaneously, reduces plasma concentrations of cyclosporine. Metamizole, which is part of the drug Spazmalgon, increases the risk of developing toxic lesions of the bone marrow due to taking chloramphenicol and other drugs that have a myelotoxic effect. Barbiturates, phenylbutazone and other enzyme inducers, when used simultaneously, reduce the therapeutic effect of metamizole. With simultaneous use of the drug with tricyclic antidepressants, allopurinol and oral contraceptives, an increase in the toxic effect of metamizole is observed. Nonsteroidal anti-inflammatory drugs, when used simultaneously with Spazmalgon, increase the risk of side effects. There is an increase in the analgesic effect of the drug when used simultaneously with tranquilizers and sedatives. When the drug is used in combination with drugs containing quinine, an increase in anticholinergic effect is noted. The drug Spazmalgon in the form of an injection solution cannot be mixed with other injection solutions in the same syringe. A combination of the drug Spazmalgon with furosemide, glibenclamide and hyoscine butyl bromide is allowed.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 °C.
Best before date
36 months
ATX classification:
N Nervous system
N02 Analgesics
N02B Analgesics and antipyretics
N02BB Pyrazolones
N02BB52 Metamizole sodium in combination with other drugs (excluding psycholeptics)
Admission rules
The dosage of the medicine for the treatment of various diseases is prescribed by the doctor. They depend on the age of the patient and the form of the drug. Spasmalgon tablets, the price of which is affordable, can be taken by adult patients once in an amount of no more than 2 pieces. You are allowed to take no more than 6 tablets per day. Allowable treatment time is 5 days. Its extension is possible only after consultation with a doctor.
Children can take the medicine no more than 2 times a day only as prescribed by the doctor. The recommended dosage for age is indicated in the instructions.
Intramuscular injections to adult patients are given 2-3 times, 2-5 ml of solution. The procedure involves slowly administering the medication. The permissible daily dosage is 10 ml. The maximum duration of treatment is 5 days. The permitted quantities of medicinal solution for children are indicated in the instructions.
